Cytegrity stable producer cell line will be used to produce the viral vector for Mustang Bio's MB-107 lentiviral gene therapy program for the treatment of X-linked
severe combined immunodeficiency.
Jude Children's Research Hospital announce MB-107 lentiviral gene therapy for X-linked
Severe Combined Immunodeficiency
Limitation on Gender Selection and Detection of X-linked
Diseases Impedes Demand Restriction on the use of PGD for human leukocyte antigen (HLA) typing and gender selection in emerging regions such as Asia Pacific could hold back growth in the global market.
Do note that there are over 100 primary immunodeficiency disorders in the world, including X-linked
agammaglobulinemia (XLA), common variable immunodeficiency (CVID) and severe combined immunodeficiency (SCID), which is known as alymphocytosis or boy-in-a-bubble disease.
This includes, but is not limited to, congenital agammaglobulinemia, common variable immunodeficiency, X-linked
agammaglobulinemia, Wiskott-Aldrich syndrome, and severe combined immunodeficiencies.?
Most cases are inherited as X-linked
defects ([gp-91.sup.phox]), but they also can occur in an autosomal recessive manner (1).
ichthyosis is an X-linked
recessive trait, in which males are affected and mothers are carriers.
Eight infants with the disorder, called X-linked
severe combined immunodeficiency (X-SCID), received experimental gene therapy.
Chronic granulomatous disease is an X-linked
or auto somal recessive condition that affects approximately 1 in 200,000-250,000 live births.
[USPRwire, Mon Feb 25 2019] X-Linked
Hypophosphatemia- Introduction X-Linked
hypophosphatemia (XLH) refers to an inherited disorder characterized by low phosphate concentration in the blood.
congenital adrenal hypoplasia (CAH) is a very uncommon genetic disorder that is caused by an abnormality in the DAX-1 gene (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1 [NR0B1]), (1) was first introduced in 1948.