X-linked SCID

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Noun1.X-linked SCID - SCID in male children resulting from mutation of a gene that codes for a protein on the surface of T cells that allows them to develop a growth factor receptor
SCID, severe combined immunodeficiency, severe combined immunodeficiency disease - a congenital disease affecting T cells that can result from a mutation in any one of several different genes; children with it are susceptible to infectious disease; if untreated it is lethal within the first year or two of life
References in periodicals archive ?
New insights and unresolved issues regarding insertional mutagenesis in X-linked SCID gene therapy.
None of the patients died developed leukemia, which has been a serious side effect in previous gene therapy studies in patients with X-linked SCID.
This led to break-throughs in treating several forms of this disorder, most notably in treating X-linked SCID (X-SCID) through use of a retrovirus to deliver the corrected gene into the patient's hematopoietic stem cells.

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