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By definition, MDR-TB are resistant at least to rifampicin and isoniazid; while XDR-TB is due to MDR strains that are resistant to all fluoroquinolones and to at least one of the three second-line injectable agents (amikacin, kanamycin and capreomycin).
After 2-3 months of treatment, she was told one day that the pre- XDR-TB drugs had stopped working and now it was a case of XDR-TB - a death sentence at that time.
The NIX-TB trial of pretomanid, bedaquiline and linezolid to treat XDR-TB.
Neither rifampicin (MIC > 100 [micro]g/ml) nor INH (MIC > 100 [micro]g/ml) inhibited XDR-TB.
At 47, Kedar is HIV positive and co-infected by XDR-TB.
XDR-TB can be cured using five or more drugs as an aggressive treatment for up to two years.
XDR-TB has been identified in 84 countries; the average proportion of MDR-TB cases with XDR-TB is 9 per cent
diagnose and treat MDR-TB, XDR-TB, and TB/HIV co-infection.
Drug-resistant forms of TB -- MDR-TB and XDR-TB and TB/HIV -- are global health priorities.
MDR-TB and XDR-TB have become a public health emergency of growing urgency worldwide.
So XDR-TB is more difficult and expensive to treat than MDR-TB (1,4).
This is the case with extensively- drug resistant TB, or XDR-TB," says Dr Kataria.
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