S100P and XIAP
expression in pancreatic ductal adenocarcinoma: potential novel biomarkers as a diagnostic adjunct to fine needle aspiration cytology.
(57) Pellino 3-deficient mice exhibit reduced NOD function and thus its polyubiquitination of RIP2 is thought to be necessary for NOD-mediated innate responses; in this regard, initial Pellino 3-mediated poly-ubiquitination may be necessary for subsequent XIAP
polyubiquitination and the two E3 ligases may act in tandem to mediate RIP2 activation.
X-kromozom baglantili IAP'yi inhibe etmek icin iki hedef yaklasim vardir: XIAP
mRNA'sini hedef alan antisens inhibitorleri ve endojen mitokondriyal IAP inhibitorlerini (SMAC) taklit eden kucuk molekul pan-IAP antogonistleridir (2).
In each section used for the immunohistochemical reaction, two microscopic fields were selected in the compact bone of the tibia at 400x magnification, where higher concentration of positive or labeled cells (areas of "hot spots") for proteins related to the mechanism of apoptosis (CASPASE 3 - pro-apoptotic and XIAP
anti-apoptotic) were present.
Martinez et al., "Erratum to: a de novo whole gene deletion of XIAP
detected by exome sequencing analysis in very early onset inflammatory bowel disease: a case report," BMC Gastroenterology, vol.
The hypothesis is that bacterial products, such as lipopolysaccharide, could activate TLR4-MyD88 axis in tumour cells followed by the production of proinflammatory cytokines, overexpression of antiapoptotic signals (XIAP
and pAkt), and, finally, acquisition of chemoresistance by ovarian cancer cells .
Recent studies have shown that both tumor suppressor p53 and XIAP
, a potent inhibitor of apoptosis, bind to the Siva-1 N-terminal and DDHR regions (11,12).
DIM potentiates chemosensitization and killing of pancreatic cancer cells by downregulation of constitutive as well as drug-induced activation of NF-kappaB and its downstream genes (XIAP
, Bcl-xL, survivin, and cIAP).
Takahashi, "A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP
, inducing cell death," Molecular Cell, vol.
Several immunohistochemical markers, including cell proliferation markers, human telomerase reverse transcriptase, p53 protein, bcl-2, platelet-derived growth factor receptor (PDGR-R), P-glycoprotein, epithelial membrane antigen (EMA), desmin, X-linked inhibitor of apoptosis protein (XIAP
), and glucose transporter isoform GLUT-1, have been tested for their ability to distinguish between benign mesothelial hyperplasia and MM.
Based on earlier studies demonstrating that myocyterestricted deletion of FAK exacerbated myocardial I/R injury , we demonstrated that cardiac-specific activation of FAK protected cardiomyocytes from I/R-induced apoptosis by enhancing NF-[kappa]B-dependent transcription of the prosurvival Bcl-2 family members Bcl-2 and Bcl-xl and X-linked inhibitor of apoptosis (XIAP
, Figure 1) .
This protective effect, including recovery of motor function and coordination, persisted over 28 days , concordant with decreased expression of Bcl2 and X-linked inhibitor of apoptosis protein (XIAP