Spatial recognition memory and motor activity were carried out in a previously described two-trial Y-maze
. In each trial, the mice were placed onto the end of one arm and allowed to explore freely for 5 min.
After viewing the initial number, each bee would fly through a hole into a decision chamber where it could either choose to fly to the left or right side of the Y-maze
depending on operation to which she had been trained for.
In both models, Y-Maze
and Positive Emotional Learning, performance was significantly impaired following repeat closed head injury.
Our findings demonstrated that wogonin inhibited amyloid precursor protein (APP) processing in the [beta]-secretase pathway, the phosphorylation of Tau protein, and A[beta] aggregation in human neuroblastoma cells and exhibited protective effects on learning and memory impairments in the Morris water maze test, Y-maze
, and the novel object recognition test of 3xTg-AD mice.
The DZP group exhibited a significantly higher number of errors (a) in the Y-maze
test as compared to the control group (p <0.001).
Caption: Figure 6: Graphic representation of the number of rearing (a and b) and grooming (c and d) of rats in the Y-maze
before and after scopolamine exposition in rats treated with different substances into the Y-maze
Previous behavioural data published by our laboratory on the same cohort of female mice found preadolescent OVX in WT mice to cause Y-maze
deficits, which were relieved by estradiol but not progesterone treatment, albeit the progesterone group was trending toward an improvement in Y-maze
Open field and Y-maze
tests were performed for Groups B and C, 1 day before the first and second PET scans.
memory task in zebrafish (Danio rerio): the role of glutamatergic and cholinergic systems on the acquisition and consolidation periods.
Our previous studies revealed that some antidepressant drugs such as paroxetine, venlafaxine, duloxetine, citalopram and bupropion, but not fluvoxamine improve spatial memory acquisition in old rats in the Y-maze
assay (11) (12) (13).
OVX also impaired object recognition performance in the novel object recognition test and spatial cognitive performance in the Y-maze
test and the water maze test.