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(Biochemistry) biochem any of a group of compounds that are inactive precursors of enzymes and are activated by a kinase


(ˈzaɪ mə dʒən, -ˌdʒɛn)

any of various enzyme precursor molecules that may change into an enzyme as a result of catalytic change. Also called proenzyme.
[< German (1875); see zymo-, -gen]
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Noun1.zymogen - any of a group of compounds that are inactive precursors of enzymes and require some change (such as the hydrolysis of a fragment that masks an active enzyme) to become active
organic compound - any compound of carbon and another element or a radical
References in periodicals archive ?
They are synthesised and secreted in the form of inactive zymogens (proenzymes) by most of cells in the human body [1].
This hydrolytic activity is given by a family of enzymes and zymogens present in the cell, called widely 'proteases', with the purpose to hydrolyze the peptide bond [7,21].
Caspases are cysteine-containing aspartic acid-specific proteases which exist as zymogens in the soluble cytoplasm, endoplasmic reticulum (ER), mitochondrial intermembrane space, and nuclear matrix [10].
At cytosolic concentrations in human cells, the caspase-3 zymogens are already dimers, but cleavage within their respective linker segments is required for activation (Boatright and Salvesen 2003).
Monocytes from patients with AD are primed to generate ROS in response to zymogens produced by Staphylococcus aureus that is heavily colonized on skin of AD patients, leading to damage of the skin barrier by ROS production [42].
Differences in proteolytic enzyme activities and zymogens in fish at different ages have been reported, but the changes have been attributed to feeding habitats or diet changes and not solely influenced by age (Falcon-Hidalgo et al, 2011; Unajak et al, 2012).
Trypsinogen, like all other zymogens, is packaged in zymogen granules, which further retard trypsinogen activation.
In detail, enterokinase was added to homogenate to activate pancreatic zymogens before determination of pancreatic trypsin and protease.
The first group composed of anionic peptides similar to the charged-neutralizing pro-peptides of larger zymogens
the activation of some zymogens of the coagulation cascade or the maturation of insulin.
The protolyzed zymogens, fibrin in vertebrates (Weisel, 2005) and coagulin in chelicerates (Kawasaki et al.
This process can be initiated by external (extrinsic or receptor-mediated) or internal (intrinsic or mitochondrial) cell stimulation; both involve a preserved group of specific aspartate cysteine-proteases called caspases that are synthesized as zymogens, which must undergo proteolytic fragmentation to activate.