Indeed, drugs such as paclitaxel, etoposide, methotrexate, and
carmustine associated to LDE had the ability to markedly reduce the lesions and the concurrent proliferative and inflammatory processes (24).
High-dose cyclophosphamide,
carmustine, and etoposide followed by allogeneic bone marrow transplantation in patients with lymphoid malignancies who had received prior dose-limiting radiation therapy.
Knopp et al., "Pattern of recurrence following local chemotherapy with biodegradable
carmustine (BCNU) implants in patients with glioblastoma," Journal of Neuro-Oncology, vol.
Meanwhile the patient underwent
carmustine therapy on the suspicion of mycosis fungoides without any apparent clinical effect.
Prior to 1999, nitrosourea-based combinations were the most commonly used chemotherapeutic agents in GBM, among which
carmustine and lomustine were the most active agents.
In the conventional melanoma chemotherapy treatment, antineoplastic agents have been a principal tool for combating cancer [10], specifically dacarbazine, temozolomide,
carmustine, lomustine, vincristine, vinblastine, cisplatin, carboplatin, taxol, docetaxel, and so forth [11, 12].
Bortey et al., "A phase 3 trial of local chemotherapy with biodegradable
carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma," Neuro-Oncology, vol.
Michalak et al., "Phase III trial of
carmustine and cisplatin compared with
carmustine alone and standard radiation therapy or accelerated radiation therapy in patients with glioblastoma multiforme: North Central Cancer Treatment Group 93-72-52 and Southwest Oncology Group 9503 Trials," Journal of Clinical Oncology, vol.