This standardised regimen consists of a 4-6 months' intensive phase with kanamycin, moxifloxacin, prothionamide, clofazimine, PZA, high-dose INH and ethambutol.
Kumar and coworkers have demonstrated the promising potential of Isoniazid (Scheme-1) in this respect by different analogues of the drug [4] Rollas et al evaluated the cytotoxic activity of hydrazones of INH and their iron complexes and proposed a mechanism of inhibition of ribonucleotide reductase [5].
High doses of INH are associated with metabolic acidosis, convulsions, rhabdomyolysis, lactic acidosis, coma, and even may cause death if not properly treated.
Tuberculosis (TB) is treated with first line drugs including streptomycin (STR), isoniazid (INH), rifampicin (RIF), ethambutol (ETB) and pyrazinamide (PZA).
Isonicotinic acid hydrazide or commonly known as isoniazid (INH) is one of the most significant anti-TB first-line drugs, which impede mycolic acid synthesis to kill actively growing intracellular and extracellular tubercle bacilli [3].
While functional anti-FceRIa and anti-lgE have the potential to play a role in histamine-mediated angioedema, C1 inhibitor (INH) deficiency or dysfunction, sometimes due to anti-C1 INH, plays a role in bradykinin (BK)-mediated angioedema.
Objective: Hereditary angioedema (HAE) is a rare autosomal-dominant disease characterized by recurring attacks of nonpruritic, nonpitting edema caused by an inherited deficiency or dysfunction in the C1 esterase inhibitor (C1 INH).
All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.