The researchers found that compared with monotherapy of either
methotrexate or a biologic, combination therapy with TNF or non-TNF biologics plus
methotrexate improved disease control, remission, and functional capacity.
Release date- 23082019 - EMA has recommended new measures to prevent serious and potentially fatal errors with the dosing of
methotrexate for treating inflammatory diseases such as rheumatoid arthritis, psoriasis and Crohn's disease.
- Irish drugmaker Horizon Therapeutics plc (NASDAQ: HZNP) has initiated a clinical trial evaluating Krystexxa (pegloticase injection) in combination with
methotrexate as a strategy to increase the durability of response for patients living with chronic gout refractory to conventional therapies also known as uncontrolled gout, the company said.
Horizon Therapeutics, an Irish-tax registered pharmaceutical company, has started clinical trial assessing KRYSTEXXA (pegloticase injection) in combination with
methotrexate as a strategy to increase the durability of response for patients living with chronic gout refractory to conventional therapies, also called uncontrolled gout, it was reported on Friday.
A second big trial designed to parallel CANTOS tested
methotrexate in roughly the same way and found it produced no cardiovascular disease benefit among high-risk patients.
A 20% improvement in ACR criteria at week 24 --the primary endpoint of the randomized, controlled study--was significantly greater in 284 patients treated with etanercept monotherapy and in 283 patients treated with combination etanercept and
methotrexate than in 284 patients treated with
methotrexate monotherapy (60.9% and 65.0% vs.
Results: Patients were separated into two groups as those who were treated with single-dose
methotrexate and those who required surgical treatment.
However at higher oncologic doses, as mentioned previously, it is this direct competition of folinic acid against
methotrexate transport that allows it to be useful in the setting of MTX overdose.
Twelve days before presentation, she was diagnosed with palmoplantar psoriasis and placed on
methotrexate 7.5 mg weekly along with folic acid 1 mg daily.
"To our knowledge, this is the first randomized controlled study of either adalimumab or
methotrexate in children and adolescents with psoriasis," the researchers said, noting that the study did not include a placebo group because of ethical issues related to treating children with a severe chronic disorder.
Her past medical history was significant for paroxysmal atrial fibrillation for which she was taking apixaban, rheumatoid arthritis for which she was taking 7.5 mg
methotrexate once a week for 6 years, coronary artery disease with left circumflex and right coronary artery stent placement 6 years ago, congestive heart failure with reduced ejection fraction for which she was taking digoxin and furosemide, diabetes mellitus type 2 on repaglinide, hypertension, and stage 4 chronic kidney disease secondary to diabetes and hypertension.