Bradykinin and the pathogenesis of hereditary angioedema.
Thirdly, ACEI-induced angioedema, a reaction, in which the inhibition of the degradation of
bradykinin is observed, resulting in angioedema, but not urticaria.
The first relates to the release of histamine and serotonin, the second (90-150 min) is mediated by the release of
bradykinin (38), and finally in the third phase, the mediator is suspected to be prostaglandin (22).
Bradykinin is a peptide that causes blood vessels to dilate, reducing blood pressure; substance P, which is also a peptide, can act as a neurotransmitter.
Effects of intracoronary administration of
bradykinin on the impulse activity of afferent sympathetic unmyelinated fiber with left ventricular endings in the cat.
Carrageenan induces inflammation through release of histamine, serotonin (early phase), prostaglandins and
bradykinin (later phase) (Burch and DeHaas, 1990).
ACE inhibitors like lisinopril act by inhibiting ACE, decreases angiotensinogen II activity and increases the
bradykinin and (met) enkaphalin.
Randomized placebo-controlled trial of the
bradykinin B2 receptor antagonist icatibant for the treatment of acute attacks of hereditary angioedema: The FAST-3 trial.
Physical Activity reduces the action of angiotensin converting enzyme (ACE), which consequently decreases the action of Angiotensin II (vasoconstrictor) and increases the bioavailability of the enzyme
bradykinin (vasodilator) (11).
Inflammation is initiated by Prostaglandins,
bradykinin and histamine.
Bradykinin (BK) is a nine amino acid vasoactive peptide that is produced by the proteolytic action of kallikrein on the precursor kininogen (KNG).