Noun | 1. | ![]() middle west, Midwest, midwestern United States - the north central region of the United States (sometimes called the heartland or the breadbasket of America) U.S.A., United States, United States of America, US, USA, America, the States, U.S. - North American republic containing 50 states - 48 conterminous states in North America plus Alaska in northwest North America and the Hawaiian Islands in the Pacific Ocean; achieved independence in 1776 Akron - a city in northeastern Ohio; the heart of the United States rubber industry Athens - a town in southeast Ohio Cleveland - the largest city in Ohio; located in northeastern Ohio on Lake Erie; a major Great Lakes port Cincinnati - a city in southern Ohio on the Ohio river capital of Ohio, Columbus - the state capital of Ohio; located in the center of the state; site of Ohio State University Dayton - a city in southwest Ohio; manufacturing center Mansfield - a town in north central Ohio Toledo - an industrial city in northwestern Ohio on Lake Erie Youngstown - a city in northeast Ohio Wabash, Wabash River - a tributary of the Ohio River that rises in western Ohio and flows southwestward across Indiana |