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An antiviral drug, C14H18N6O, that is a nucleoside reverse transcriptor inhibitor and is used in its sulfate form in combination with other drugs for the treatment of HIV infection.

[aba- (perhaps from ab, first two letters of the alphabet, from the fact that it was the first of this type of antiviral developed) + -c(arbocyclic nucleoside), nucleoside whose oxygen in the sugar ring has been replaced by a carbon + a(nti)vir(al) .]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


n abacavir m
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
References in periodicals archive ?
Another 5 patients developed hypersensitivity reactions to abacavir but didn't share this complete sequence of gene variants.
At the heart of the dispute is a researcher who, the institution says, invented the Aids drug Ziagen, known generically as abacavir.
(NASDAQ: GILD) has released detailed 48-week results from a Phase 3 study evaluating the efficacy and safety of switching from a regimen containing abacavir, dolutegravir, and lamivudine (600/50/300mg) (ABC/DTG/3TC) to Biktarvy (bictegravir 50mg/emtricitabine 200mg/tenofovir alafenamide 25mg), a once-daily single tablet regimen, in virologically suppressed adults with HIV, the company said.
M2 EQUITYBITES-March 30, 2017-Aurobindo Pharma gains US FDA approval to manufacture abacavir sulfate and lamivudine tablets
Tenofovir was chosen as the comparator for the trial as it is currently the 'gold standard' in many guidelines, and the alternatives (zidovudine (AZT) and abacavir) are now more expensive than tenofovir.
A major government clinical trial comparing three HIV treatments stopped the arm using abacavir plus AZT plus 3TC (Trizivir[R]) alone, after patients in that arm " experienced virologic failure earlier and more frequently than patients who were randomized to receive either of the other two treatment regimens being evaluated in the study." However, all three of the study arms seemed to do well virologically, given the relatively advanced HIV infection the volunteers started with.
* Combivir: On May 10, GlaxoSmithKline announced that it had received four reports of bottles labeled as containing 60 tablets of Combivir (AZT plus 3TC) which actually contained another antiretroviral, Ziagen[R] (abacavir); the FDA also sent warnings.