Also found in: Thesaurus, Medical, Wikipedia.
Related to acantholysis: pemphigus, acanthosis, dyskeratosis, spongiosis, pemphigus vulgaris, bullous pemphigoid
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.acantholysis - a breakdown of a cell layer in the epidermis (as in pemphigus)acantholysis - a breakdown of a cell layer in the epidermis (as in pemphigus)
disease of the skin, skin disease, skin disorder - a disease affecting the skin
pemphigus - a skin disease characterized by large thin-walled blisters (bullae) arising from normal skin or mucous membrane
References in periodicals archive ?
The binding of autoantibodies results in acantholysis and blistering, without a requirement for complement or inflammatory cells.
Tannic acid induces in vitro acantholysis of keratinocytes via IL-1 alpha and TNF-alpha.
In addition, you may see acantholysis of the follicular epithelium," Dr.
A defect in keratinocyte desmosomes leads to keratinocyte acantholysis, which clinically manifests as fragile skin that may form vesicles and bullae (5).
Signs of the classic HSV cytopathic effect included the presence of intracellular proteinaceous fluid, ballooning degeneration of epithelial cells, and acantholysis (figure 2, A) as well as intranuclear inclusion bodies and a ground-glass appearance of some nuclei (figure 2, B).
Hyperkeratosis, acantholysis, dyskeratosis, and suprabasilar clefts were also focally present.
Other areas of the palpebral conjunctivae and skin showed inflammatory foci in the epithelium without ulcer formation but with ballooning degeneration of epithelial cells, acantholysis, and occasional cell necrosis.
Additionally, there is typically a vesicle (early) or ulceration (late) with surrounding pale and/or ballooning keratinocytes, acantholysis, and necrosis (Figure 1, A).
Bystryn JC, Grando SA: A novel explanation for acantholysis in pemphigus vulgaris: the basal cell shrinkage hypothesis.