acantholysis


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Noun1.acantholysis - a breakdown of a cell layer in the epidermis (as in pemphigus)acantholysis - a breakdown of a cell layer in the epidermis (as in pemphigus)
disease of the skin, skin disease, skin disorder - a disease affecting the skin
pemphigus - a skin disease characterized by large thin-walled blisters (bullae) arising from normal skin or mucous membrane
References in periodicals archive ?
Acantholysis was seen in 27 cases (87.1%) and this was comparable to the study done by Arya et al.5 Row of tombstone appearance was seen in 25 (80.6%) cases and this was higher to that seen in Arya et al.5 study.
The histologic hallmark of PV and PF is acantholysis.
The importance of doing a simple bedside Tzanck smear in blistering disorders is very evident here, as the presence of both primary and secondary acantholysis could be demonstrated in the same smear.
The acantholytic microscopic variant of squamous cell carcinoma is characterized by extensive acantholysis resulting in pseudoglandular or pseudovascular spaces.
It can be considered as a chronic organ-specific disorder because the autoimmune injury which leads to the formation of intraepidermal blisters and acantholysis is confined to the skin and mucosa.
Histopathology shows areas of intraepidermal acantholysis causing the "dilapidated brick-wall" appearance.
This leads to an intraepithelial loss of adhesion called acantholysis, and clinically it presents with vescicles and blisters [1].
The binding of autoantibodies results in acantholysis and blistering, without a requirement for complement or inflammatory cells.
Histopathology shows suprabasal clefting, acantholysis, and dyskeratosis with appearance of corps ronds and grains.
Ultimately, the mutation leads to impaired cell-to-cell adhesion with the common histological findings of suprabasal acantholysis and dyskeratosis of cells in the epidermis.
Additionally, there is typically a vesicle (early) or ulceration (late) with surrounding pale and/or ballooning keratinocytes, acantholysis, and necrosis (Figure 1, A).
Histopathological examination showed suprabasal partial acantholysis. "Dilapidated brick wall" appearance was also seen.