Focal epidermal necrosis, acanthosis ballooning degeneration, and acantholysis
of keratinocytes were observed.
Pemphigus is demonstrated by acantholysis
and immunoglobulin deposits in the interkeratinocyte substance.
1] Pemphigus is caused by autoantibody (IgG) deposition against Desmoglein (1 and 3) antigens located in the desmosomes of epidermal keratinocytes or 9[alpha] nicotinic acetylcholine receptors, leading to acantholysis
and intraepidermal cleft formation.
Desmosome function is disrupted by autoantibodies (Abs), resulting in acantholysis
of keratinocytes in the epidermis.
Pemphigus is an uncommon autoimmune condition in which circulating autoantibodies against intercellular adhesion molecules result in acantholysis
, or loss of keratinocyte adhesion.
Skin biopsy was performed on the abdominal skin lesion and the histology showed suprabasal acantholysis
with bullous cleft formation, which was compatible with PNP [Figure 1]f.
Presence of acantholytic cells in the granular layer (arrow), neutrophilic PMN (circle) and acantholysis
5%), basal layer vacuolization (85%), acantholysis
At day 4pi, animals C1V1 and C2V2 had acanthosis, mild multifocal acantholysis
and moderate focal hyperkeratosis, with focally extensive loss of epidermal layers (ulcer) and focally extensive necrosis with intralesional aggregate of basophilic coccoid bacteria (Figure 2A e 2C).
The benign mucosa may show spongiosis, acantholysis
, degeneration, and reactive atypia that mimic carcinoma or dysplasia.
This is an uncommon and rare histopathologic variant of SCC, characterised by acantholysis
of the tumour cells, creating pseudo lumina and false appearance of glandular differentiation.
Some researchers have proposed that Grover's disease is caused by obstructed sweat glands that lead to pooled sweat urea coming out of the epidermis, resulting in acantholysis