nigricans in an otherwise healthy young child.
Se encontro un 78.5% con historial familiar de diabetes, 74.2% estaban sobrepeso, y 48% tenian acanthosis
His younger brother has tested positive for acanthosis
nigricans, a predictor of insulin resistance.
* Signs of insulin resistance or conditions associated with insulin resistance (acanthosis
nigricans, hypertension, dyslipidemia, PCOS)
3) There is an acanthosis
of the stratum spinosum in the epithelial mid-layer.
The commonest recognized histopathological features were saw-toothed rete ridges/ irregular acanthosis
, vacuolar degeneration of basal layer and band like infiltrate in our study.
Accordingly, because DM2 is preceded by a period of IR, the measurement of both fasting insulin and glucose in children and adolescents with obesity is recommended, particularly in subjects who had the presence of acanthosis
nigricans and a family history of DM2 [1, 2, 8-10].
Clinical findings of RMS include acanthosis
nigricans, generalized lanugo, tooth and nail dysplasia, high nasal bridge, growth retardation, and hyperextensible joints (4).
(1) Initially, the distinct entity of CARP was contested, with some dermatologists believing it to be a variant of acanthosis
Histology of PR reveals focal parakeratosis in the epidermis in mounds with exocytosis of lymphocytes, variable spongiosis, mild acanthosis
, and a thinned granular layer.
Significant hyperkeratosis, acanthosis
, papillomatosis, focal and large globular amorphous material in the papillary dermis, scattered and periappendageal mononuclear cell infiltration in the dermis were seen in lichen amyloidosis (Figures 3) while basal layer pigmentation and dermal melanophages was seen in macular amyloidosis (Figures 4).
A punch biopsy from the lesion showed pseudoepitheliomatous hyperplasia with hyperkeratosis, acanthosis
[Figure 2(a), H and E (40x), and Figure 2(b), H and E (400x)], and dense inflammatory infiltrates with epithelioid cells and giant cells in the dermis with few acid fast bacilli (AFB) [Figure 2(c), H and E (400x), and Figure 2(d), ZN Staining (1000x)].