Of note, 2015 was considered the year with the highest incidence of whooping cough since the introduction of the acellular vaccine
There is intriguing preliminary evidence from a study in baboons conducted by scientists at the Food and Drug Administration that suggests acellular vaccine
doesn't protect against pertussis infection and transmission, even though symptoms are prevented (Proc Natl Acad Sci USA.
The old vaccine used whole cells of the pertussis bacterium, while the new acellular vaccine
uses only components of the disease-causing cells.
While both types of vaccine resulted in robust anti-body responses in the animals, those that received an acellular vaccine
had the bacteria in their airways for up to six weeks after vaccination and were able to spread the infection to unvaccinated animals.
A contributing factor could be the switch from the whole cell to the acellular vaccine
, which may have an effect on how long immunity persists.
While admitting that the whole-cell pertussis vaccine was crudely made and contained more than 3,000 pertussis proteins, Offit tells nothing of the saga of replacing this with the much safer acellular vaccine
, a story told in detail by David and Mark Geier.
Thus, Si has been the target of many studies as a potent candidate of acellular vaccine
against Bordetella pertussis, lacking the side effects of whole cell based ones.
The duration of protection from the acellular vaccine
has not yet been determined, but the efficacy appears similar to that of the whole cell vaccine (AAP, 1997a).
contains on the 2-4 antigens thought to be most important in developing immunity.
"What drove acellular vaccine
development was misinformation about encephalopathy," Cherry says.
The study found teens who were vaccinated with four doses of acellular vaccine
were at almost six times higher risk of pertussis than those who had received four doses of whole-cell vaccine.