M2 PRESSWIRE-July 31, 2019-: Global Acetazolamide
Market Expected to Grow by 4.1% During the Forecast Period, 2019-2025
, a diuretic, to prevent and treat high altitude sickness
Saito has tested positive for acetazolamide
, a diuretic, in an out-of-competition check.
Given his history of recurrent attacks of vertigo and ataxia, he was started on acetazolamide
with a significant reduction in symptoms, in both severity and frequency, to once per month, compared to several times per week.
Unfortunately there are several misperceptions in the article, and I would like to focus on the use of acetazolamide
. The authors do not seem to be clear about the fact that there is strong evidence for the role of acetazolamide
in the prevention of AMS.
There are many effective inhibitors of CAs, most of classical sulfonamides/sulfamates CA inhibitors and their derivatives, such as ethoxzolamide (EZA), acetazolamide
(AZA), do not have a good selectivity of CA-IX, over the sulfonamide-avid against iso-zyme CA-II [8-10].
Timolol + brimonidine (30.76%) was the most frequently prescribed FDC followed by topical timolol + oral acetazolamide
intramuscularly for 3 days and Acetazolamide
(Diamox (b)) at dose rate 3mg/kg b.
Before the 6-month assessment, 91% of the patients received a median daily dose of 623 mg of acetazolamide
. Weight loss was achieved in 31% of the patients and steady weight in 48%, whereas 21% presented weight gain.
Besides prevention through slow ascent and inclusion of resting days between ascents [89,90], AMS can also be prevented effectively by acetazolamide
or dexamethasone [91-93], and these two medications are each recommended by the Wilderness Medical Society with an evidence level of 1A [91-94].
If weight loss is inadequate, acetazolamide
(Diamox), a carbonic anhydrase inhibitor, is the initial drug of choice.
One group was giventopical 2% dorzolamide, second was given oral acetazolamide
and the third group received no medicines prior to capsulotomy.