acetoacetic acid

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Related to acetoacetate: methyl acetoacetate

ac·e·to·a·ce·tic acid

 (ăs′ĭ-tō-ə-sē′tĭk, ə-sē′tō-)
An organic acid, C4H6O3, that is one of the ketone bodies that accumulate in the blood and urine when fat is being metabolized.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

a•ce•to•a•ce′tic ac′id

(əˌsi toʊ əˈsi tɪk, -əˈsɛt ɪk, ˌæs ɪ toʊ-)
a colorless, oily liquid, C4H6O3, soluble in water, alcohol, and ether: used in synthetic organic chemistry.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.acetoacetic acid - unstable acid found in abnormal amounts in the blood and urine in some cases of impaired metabolism (as diabetes mellitus or starvation)acetoacetic acid - unstable acid found in abnormal amounts in the blood and urine in some cases of impaired metabolism (as diabetes mellitus or starvation)
acetone body, ketone body - a ketone that is an intermediate product of the breakdown of fats in the body; any of three compounds (acetoacetic acid, acetone, and/or beta-hydroxybutyric acid) found in excess in blood and urine of persons with metabolic disorders
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References in periodicals archive ?
Another study showed that acetoacetate and BHB were affected by increasing transamination of glutamate to aspartate and conversion to gamma-aminobutyric acid (10).
As can be seen, 15 (glucose, lactate, pyruvate, acetoacetate, BHBA, fumaric acid, citric acid, choline, glycine, proline, isoleucine, leucine, urea, creatinine, and orotic acid) of the 33 potential biomarkers were also discovered in blood or milk in our previous studies [4,5].
This group had higher levels of acetoacetate and acetate than the NGT group (Figure 4) and the highest level of 3-HIB; no differences in BCAAs were found (data not shown).
It is metabolized sequentially into 3-hydroxy-3-methylglutaryl-CoA and then into acetoacetate (Figure 1) [9].
The conventional methods employed for the synthesis of substituted isoxazole-5(4H)ones, include cyclization of O-propioloyl oximes [27], reaction of ethyl acetoacetate and hydroxylamine hydrochloride followed by the Knoevenagel condensation with aromatic aldehydes in two steps [28-30], condensation of substituted benzaldoximes and 1,3-dicarbonyl compounds [31], and reaction of [beta]-oxoesters with hydroxylamine and sodium hydroxide with subsequent addition of aqueous HCl followed by heating [32].
Peng et al., "Acetoacetate induces hepatocytes apoptosis by the ROS-mediated MAPKs pathway in ketotic cows," Journal of Cellular Physiology, vol.
Ethyl acetoacetate: A potential bio-based diluent for improving the cold flow properties of biodiesel from waste cooking oil.
Ketones (primarily beta-hydroxybutyrate and acetoacetate) are formed in the liver from the newly released fatty acids, and released into the circulation, including into the brain during times of decreased glucose availability--a state characteristic of Alzheimer's disease.
Although urine ketone dipsticks tests routinely measure urinary acetoacetate, they do not detect the ketone predominant in HG, which is [beta]-hydoxybutyric acid ([beta]-HBA).
Allelochemical ethyl 2-methyl acetoacetate (EMA) induces oxidative damage and antioxidant responses in Phaeodactylum tricornutum.
Ketone bodies are three small water-soluble molecules of acetoacetate, 3-hydroxybutyrate, and acetone.
The pKa of an acetoacetate C-H is around 10.7; for a malonate, it is even higher (>13).