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Besides, reacting with amines and alcohol, diketene tends to correspond to acetoacetic acid derivatives.
A combination of elevated blood glucose in the setting of depleted insulin availability creates an acidic environment from the production of [beta]-hydroxybutyric acid and acetoacetic acid [1].
On Saturday an average of a 19.3 km hike was made driving the patient into a postexercise ketogenic state lasting into Wednesday or Thursday as confirmed by urine acetoacetic acid ketone test strips.
In order to develop a convenient, accessible, and high yield method for preparing of 6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one, in present investigation acetoacetic acid ethyl ester was treated with thiourea in sodium methylate (Scheme 1).