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 (ə-sēt′l-kō′ā′, ăs′ĭ-tl-)
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Acetyl CoA carboxylase is catalyze to first phase of fatty acid biosynthesis and it synthesizes the palmitic acid.
SIRT1 and SIRT6), HDACs, and HATs, which require acetyl CoA from the TCA cycle; nutrient sensing through the AMPK and mTOR signaling pathways; DDR mediated by PARP, ATM, SIRT1, and AMPK; and redox signaling through overlapping pathways mediated by ATM/Chk2, p53, Hif1-[alpha], ERK, and NF[kappa]B.
28) Similarly, acetate is metabolized to acetyl CoA and cholesterol via the cholesterol biosynthetic pathway.
The earlier work carried out in our laboratory on the biochemical action of polyphenolic acetates, PA(s) focused our attention on the role of enzymatic acetylation of protein independent of Acetyl CoA (8).
In cells with mitochondria that contain enzymes capable of transforming acetate to acetyl CoA, such as heart, skeletal muscle, and brain, the acetate is eventually metabolized to C[O.