acetylation


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Related to acetylation: methylation, acetic anhydride, acylation

a·cet·y·late

 (ə-sĕt′l-āt′)
tr.v. a·cet·y·lat·ed, a·cet·y·lat·ing, a·cet·y·lates
To bring an acetyl group into (an organic molecule).

a·cet′y·la′tion n.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.acetylation - the process of introducing an acetyl group into a compoundacetylation - the process of introducing an acetyl group into a compound; "the acetylation of cyclooxygenase-2 by aspirin"
acylation - the process of introducing an acyl group into a compound
References in periodicals archive ?
KDAc Therapeutics is a biotechnology company founded on technologies licensed from the Broad Institute of MIT and Harvard to translate discoveries in lysine acetylation and epigenetic regulation into novel treatments for cancer patients.
Redox imbalance and increased protein acetylation was found in heart tissue from mice and human patients in advanced staged heart failure.
Unlike the other HDAC family members, HDAC6 is mainly located in the cytoplasm and has little effect on DNA histone acetylation. CS3003 has the potential to be combined with PD-(L)1 antibody drugs in solid tumours to expand the clinical efficacy of immunological checkpoint inhibitors.
In work leading to this proposal we identified histone acetylation as a major transcriptional regulator of plant growth and immunity.
The main epigenetic mechanisms that in mammalian cells contribute to the regulation of gene expression include DNA methylation, histone post-translational modifications (such as methylation, acetylation, phosphorylation), and ubiquitination (21).
Although it didn't reduce aortic inflammation, adalimumab had a positive effect on glycoprotein acetylation, a marker of inflammation and subclinical cardiovascular disease in psoriasis.
To date, the most commonly epigenetic changes include DNA methylation and histone modifications, such as methylation and acetylation at lysine residues.
Acetylation and deacetylation of histones are controlled by histone acetyltransferases (HAT) and histone deacetylases (HDACs), respectively.
Interestingly, [N.sup.6]-formyllysine residues were found to be refractory to acetylation in cells and in vitro (Edrissi et al.
Protein acetylation is a common posttranslational modification which may rank second to protein phosphorylation [10].