The main goal of this study is the application of systematic strategies of characterization in order to optimize the biocomposite composition based on graphite-epoxy that incorporates acetylcholinesterase
(AChE) on the matrix.
inhibition assay was carried out as per the method of Ellman [9,10] modified .
Pohanka, "Biosensors containing acetylcholinesterase
and butyrylcholinesterase as recognition tools for detection of various compounds," Chemical Papers, vol.
This work was part of a pilot study that aimed to evaluate biochemical markers such as AST, ALT, creatinine, urea, total protein, and oxidative markers such as lipid peroxidation, damage to proteins and the activity of the enzymes acetylcholinesterase
(AChE) and catalase (CAT) in farmers, worked at Fazenda Itaiba in the district of Ibiruba, Rio Grande do Sul, Brazil, exposed to different pesticides for at least five years.
Among the various biomarkers of pesticide exposure, the family of cholinesterase viz., acetylcholinesterase
(AChE) and butyrylcholinesterase (BChE) has widely been used as biomarkers to evaluate the noxious effects of pesticides i.e.
Patients with a low UPSIT score who were assigned to donepezil showed a mean 10.4point improvement on the Selective Reminding Test, while those with an UPSIT score of 30 or more showed a 2.7-point improvement in response to the acetylcholinesterase
Although the etiology of Alzheimer's disease (AD) is not fully understood, nevertheless, inhibition of acetylcholinesterase
(AChE) and butyrylcholinesterase (BChE) activity has been accepted as an effective treatment/management strategy against mild AD [6, 7].
Fingerman, "Inhibition of acetylcholinesterase
activity in the central nervous system of the red swamp crayfish, Procambarus clarkii, by mercury, cadmium, and lead," Bulletin of Environmental Contamination and Toxicology, vol.
Kufrevioglu, The behavior of some calcones on acetylcholinesterase
and carbonic anhydrase activity, Drug Chem.
inhibitors are mostly a symptomatic treatment but some claims are made about a neuroprotective effect.
Guidelines of care in many countries recommend prescribing an acetylcholinesterase
inhibitor to persons with Alzheimer's disease, if there is no contraindication for use.
Acetylcholine levels are regulated by an enzyme called acetylcholinesterase
. An efficient way to boost acetylcholine in the brain is to reduce activity of the enzyme (acetylcholinesterase
) that degrades this vital neurotransmitter (acetylcholine).