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The failure of a ring of muscle fibers, such as a sphincter of the esophagus, to relax.

[New Latin : a- + Greek khalasis, relaxation (from khalān, to loosen).]


(Medicine) pathol failure of the cardiac sphincter of the oesophagus to relax, resulting in difficulty in swallowing
[New Latin, from a-1 + Greek chalasis relaxation]


(ˌæk əˈleɪ ʒə, -ʒi ə, -zi ə)

inability of a circular muscle, esp. of the esophagus or rectum, to relax, resulting in widening of the structure above the muscular constriction.
[1910–15; a-6 + Greek chálas(is) (chala-, s. of chalân to loosen + -sis -sis) + -ia]


n. acalasia, falta de capacidad de relajación esp. de una abertura o esfínter.


n acalasia
References in periodicals archive ?
Among their topics are fundoplication for gastroesophageal reflux disease, endoscopic therapy for Barrett's esophagus: who and how, whether there is a role for endoscopic therapy in achalasia, the minimally invasive management of benign esophageal tumors and cysts, and the contemporary management of iatrogenic and non-iatrogenic esophageal injuries.
Triple A (Allgrove) syndrome, an autosomal recessive disease is characterized by achalasia, alacrimia and ACTH-resistant adrenal failure with progressive neurological syndrome including central, peripheral and autonomic nervous system impairment, and mild mental retardation.
IW-1701 has been shown in non-clinical studies to modulate the nitric oxide/soluble guanylate cyclase/cyclic guanosine monophosphate (NO/sGC/cGMP) signaling pathway, which is believed to be implicated in achalasia and sickle cell disease, and is being investigated for its potential to treat multiple aspects of sickle cell disease pathophysiology, including red blood cell sickling, decreased blood flow, and vascular inflammation.
Gastroesophageal reflux disease, alkali or acid ingestion, achalasia due to unknown aetiology are considered as main causative factors in the genesis of benign lesions.
This study also included rather rare specific benign lesions that produce significant increases in the wall thickness, including eosinophilic gastritis, achalasia of the cardia, hypertrophic pyloric stenosis, TB, and sarcoidosis.
Objective: The study was carried out to ascertain the outcome of laparoscopic modified Heller's myotomy for achalasia cardia and to determine the morbidity associated with it.
Objective: To evaluate the results of single session of endoscopic balloon dilation with 30mm pneumatic balloon for achalasia, over a prolonged ([greater than or equal to]12 months) observation period.
He had a history of laparoscopic fundoplication and myotomy for achalasia ten years ago.
1) Achalasia is characterised by oesophageal aperistalsis and increased resting pressure with partial or incomplete relaxation of the lower oesophageal sphincter.
Osophagogastroduodenal (EGD) graphy was taken for achalasia, alacrima, adrenal failure (AAA) syndrome and ranitidine treatment was initiated because moderate reflux was found.
Case of Achalasia of the Cardia relieved by Operation.
Eventually she was told she suffered from a condition called achalasia, an auto immune disease, for which there is no known cause and which affects around 6,000 people in the UK.