Although the rash is sometimes called acneform
, it is not acne, and acne treatments will only irritate it further.
In clinical studies of ERBITUX, dermatologic toxicities, including acneform
rash, skin drying and fissuring, paronychial inflammation, infectious sequelae (eg, S.
rash occurred in 1-17% of patients.
Of 12% (42), 8% (28) were Nevirapine rash[ erythema multiforme and acneform
eruptions] and 4%(14) were Lichenoid eruptions.
It begins by explaining the structure and function of the skin, hair and nails, approaches to diagnosis, bacterial and viral infections, fungal infections, ectoparasite infections, acne, acneform
eruptions, rosacea, eczema, psoriasis, benign and malignant skin tumors, naevi, and disorders involving genetics.
The disease, which became known as Yusho or "rice oil disease," was first characterized by its dermal manifestations including acneform
lesions, brown pigmentation of the skin, and ocular swelling.
Chloracne or other Acneform
Disease consistent with Chloracne,
rash usually developed within the first two weeks of therapy
rash usually developed within the first two weeks of therapy and resolved in a majority of the patients after cessation of treatment, although in nearly half, the event continued beyond 28 days
Symptoms resemble a sinus cold with gastrointestinal upset and acneform
skin lesions, all of which resolve spontaneously when excess intake stops (60).
The most frequent adverse events seen in patients with metastatic colorectal cancer (n=354) treated with ERBITUX plus irinotecan in clinical trials (incidence 50%) were acneform
rash (88%), asthenia/malaise (73%), diarrhea (72%), and nausea (55%).
The most frequent adverse events seen in patients with carcinomas of the head and neck receiving ERBITUX in combination with radiation therapy (n=208) versus radiation alone (n=212) (incidence 50%) were acneform
rash (87%/10%), radiation dermatitis (86%/90%), weight loss (84%/72%), and asthenia (56%/49%).