The most commonly reported treatment-emergent grade 2 or higher AEs were acneiform
rash in 53% (10/19), fatigue in 26% and nausea in 21% of patients.
Blockade of the EGFR molecule leads to dermal changes, however, presenting as acneiform
rash, skin fissure and xerosis, and pruritus.
Zaenglein, MD, has composed a whimsical couplet to help physicians broaden their differential diagnosis for acneiform
rashes in children.
Comment: Hidradenitis suppurativa is a chronic painful acneiform
condition affecting the axillae, groin, and other areas that contain apocrine glands.
The most common (>5% incidence) Grade =3 adverse events occurring at a higher rate (=5% difference) on the CYRAMZA-plus-erlotinib arm compared to the placebo-plus-erlotinib arm were hypertension, dermatitis acneiform
(an acne-like rash), and diarrhoea.
The most common Grade 3 adverse events occurring at a higher rate on the Cyramza-plus-erlotinib arm compared to the placebo-plus-erlotinib arm were hypertension, dermatitis acneiform
The keratinized tissue condition is selected from the group consisting of acneiform
eruptions, autoinflammatory syndromes, chronic blistering, conditions of the skin appendages, dermatitis, drug or agent eruptions, infection-related, papulosquamous hyperkeratosis, palmoplantar keratodcrmas, pruritis, psoriasis, conditions resulting from physical factors, or ionizing radiation-induced conditions, according to the patent.
The initial complaint of the patient was the acneiform
lesions on his face; this condition was managed separately, and appropriate treatment was recommended.
In our review of eighty-one cases reported in the Middle East and North Africa, we found variable incidence of mucocutaneous lesions that include multiple depressed acneiform
scars on the face and extremities (96.29%, 78 cases), beaded eyelid papules (86.41%, 70 cases), thickening of the skin (51.85%, 42 cases), verrucous plaques on the knee and elbow (37.03%, 30 cases), involvement of the tongue (55.55%, 45 cases), and thickening of the frenulum (48.14%, 39 cases) [Table 3].
The skin changes were supravenous hyperpigmentation [Figure 2], generalised pruritis, facial pigmentation, acneiform
(Papulopustular) eruptions, xerosis, hyperpigmentation of palm and sole, and toxic epidermal necrolysis, acral erythema, hand-foot syndrome, extravasation, erythema nodosum and flagellate dermatitis.
Other adverse drug reactions were acneiform
drug eruptions, DRESS, drug-induced hyperpigmentation, drug-induced onycholysis, and SJS.
In addition to fever, facial acneiform
lesions were also noticed.