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Related to acromegalic: acromegalic gigantism


A chronic disorder caused by overproduction of human growth hormone usually by the pituitary gland, characterized by enlargement of the bones of the extremities and the skull and often by the development of complications such as diabetes, hypertension, and osteoarthritis.

[French acromégalie : Greek akron, top, extremity (from neuter of akros, extreme; see acro-) + Greek megas, megal-, big; see meg- in Indo-European roots.]

ac′ro·me·gal′ic (-mĭ-găl′ĭk) adj. & n.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.acromegalic - marked or affected by enlargement or hypertrophy of the extremities or the face; "a protruding acromegalic jaw"
unshapely - not well-proportioned and pleasing in shape; "a stout unshapely woman"
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
After non-effective pituitary surgery, somatostatin receptor ligand (octreotide LAR) and/or dopamine agonist (cabergoline) were used in acromegalic patients to achieve hormonal and/or tumor control.
Cure rate after endoscopic surgery was 50% in acromegalic patients.17 For secretory adenomas D'Haens et al.18 reported an increased cure rate (50%-65%) with endoscopic removal.
Other complaints were decreased level of consciousness, decreased vision, vomiting, hearing loss, acromegalic features, numbness, proptosis, cerebrospinal fluid (CSF) rhinorrhoea, altered behaviour, ataxia, blindness, dysphagia, oculomotor nerve palsy, diplopia, vertigo, monoplegia, post-auricular discharge and tinnitus.
Oner et al., "Complete surgical resolution of bilateral total opthalmoplegia without visual field defect in an acromegalic patient presented with pituitary apoplexy," Endocrine Journal, vol.
Chanson et al., "Slow release lanreotide treatment in acromegalic patients previously normalized by octreotide," The Journal of Clinical Endocrinology & Metabolism, vol.
An SSTR5 mutation in tumor tissue was reported in one acromegalic patient who was resistant to SST analog treatment, which implies a role for SSTR5 in predicting response.[sup][29] SSTR5 expression on the top of SSTR2 reportedly may account for long-term suppression of hormone hypersecretion [sup][24] and tumor growth.[sup][30] Additional studies with a larger number of cases are necessary to establish the exact role of SSTR5 in OCT therapy for TSHoma.
Early postoperative indicators of late outcome in acromegalic patients.
[14] showed that significant increase in GH level in acromegalic patients group compared to control group.
Control of tumor size and disease activity during cotreatment with octreotide and the growth hormone receptor antagonist pegvisomant in an acromegalic patient.
The aim of this study was to investigate association between the frequencies of LEP and LEPR gene polymorphisms and subclinical atherosclerosis in acromegalic patients.
Acromegalic patients have a deficient activation of brain areas associated with memory, in this case, the temporal and prefrontal region.