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A possible Association between manganese superoxide dismutase genotypes and antioxidants markers in acromegaly patients.
Background: Acromegaly is associated with increased morbidity and mortality related to cardiovascular diseases.
Cognitive dysfunctions associated with acromegaly may be justified by the fact that changes in structure and function occur in time and they are not fully reversible even if GH and IGF1 values normalize under treatment.
Som is a Swiss/US based biopharmaceutical company focused on developing novel somatostatin analogue peptide medicines for patients with rare neuroendocrine diseases with high unmet need, principally focused on additional orphan drug candidates to address acromegaly and Cushing's disease.
[USPRwire, Mon Feb 01 2016] Global Markets Direct's, 'Acromegaly - Pipeline Review, H2 2015', provides an overview of the Acromegaly's therapeutic pipeline.
The doctor may be found negligent for missing the diagnosis of acromegaly and accompanying sleep apnea, and for failing to treat and warn about driving risks.
Obstructive sleep apnea is a well-recognized complication of acromegaly with its bony and soft-tissue hypertrophy.
Excessive production of growth hormone (GH) and insulin-like growth factor (IGF) results in the development of acromegaly. This multisystem disease usually begins between 25 and 40 years of age and occurs at similar rates among men and women (1-3).
(7) Acromegaly: 50% of patients with growth hormone adenomas were associated with hyperprolactinemia.[sup][1] (c) Drug factors, some drugs increased secretion of prolactin by antagonizing prolactin release inhibitory factor and increasing prolactin-releasing factor leading to reducing the role of dopamine.
Acromegaly is a clinical syndrome resulting from excessive production of growth hormone (GH).
Therefore, the term "excessive GH secretion" is used instead of "acromegaly" (3, 4).
Progressive enlargement of the hands and feet is also observed in acromegaly (1).