BGU and Weizmann Institute of Science researchers have disproved an old model of how actin filaments
in cells generate waves while offering a distinct framework that goes beyond the basic understanding of functionality and offers new strategies that might eventually be relevant to cancer detection and treatment.
Early molecular level studies investigated this coupling in the sliding assay system in which actin filaments
move along myosin molecules attached to a glass slide, (3),(4) but because a variable number of myosin molecules interact with the actin at a given moment, conclusions at the single molecule level could not be made.
Two other kinds of shorter projections from epithelial cells are widely distributed over the epidermis of a variety of ctenophores: non-motile cilia with a remarkable, onion-like root structure, and thick pegs containing a large bundle of actin filaments
(5, 6, 9-15).
8) The inclusions have been shown to be made up of densely packed vimentin and actin filaments
sup] As a protein that affects the dynamics of the actin cytoskeleton via stabilization of actin filaments
, transgelin is both directly and indirectly involved in many processes such as migration, proliferation, differentiation, and apoptosis.
For example, it controls the building up and breaking down of actin filaments
This complex is responsible for the nucleation of new actin filaments
and elongation of existing actin filaments
and is thus crucial to cytoskeletal dynamics such as reorganization and polymerization.
In our model, actin filaments
can be manually slided over myosin filaments as is given in the sliding filament theory of muscle contraction and Z disc also move along with movement of actin filaments
2+] ions concentration [8, 9], the content of which determines the depolymerization of actin filaments
during the swelling among many cell types .
Microtubules (red) and actin filaments
(purple) help give the synaptic bouton structure and move cargo around inside the neuron.
He said that they have discovered that Plasmodium actin filaments
are very different from other actin filaments
and now that they know the structural basis for this, we can look for ways to specifically interfere with the parasite cytoskeleton to the of this protein in the parasite in high detail.
myosin motor proteins which hydrolyze ATP (adenosine triphosphate), and thin actin filaments