Ortho Dermatologics is one of the largest prescription dermatology businesses dedicated to helping patients in the treatment of a range of therapeutic areas, including psoriasis, actinic keratosis
, acne, atopic dermatitis and other dermatoses.
[ClickPress, Wed May 08 2019] Actinic keratosis
is prevalent as the initial clinical manifestation of a disease continuum in sun-damaged skin which may led to invasive squamous cell carcinoma.
Treatment failure--less than 75% clearance of actinic keratosis
at 3 months after the final treatment--was seen after one treatment cycle in 14.8% of patients treated with fluorouracil, 37.2% of patients on imiquimod, 34.6% of patients given photodynamic therapy, and 47.8% of patients on ingenol mebutate therapy.
Rudolf Kwan, Athenex's chief medical officer, said, "These two pivotal studies confirmed that KX2-391 ointment 1% is well tolerated and active as a field treatment of actinic keratosis
of the face and the scalp, with LSRs that are mostly mild and transient.
Local destruction with cryosurgery is the first-line treatment for verruca vulgaris, actinic keratosis
and molluscum contagiosum.
KX2-391, also known as KX-01, is a first-in-class dual Src kinase and tubulin polymerization inhibitor in Phase III development as a topical medicinal product for the treatment of actinic keratosis
. Actinic keratosis
is a common skin condition that is induced through ultra-violet light damage, resulting in patches of thick, scaly, or crusty skin.
Guillen et al., "A consensus approach to improving patient adherence and persistence with topical treatment for actinic keratosis
," International Journal of Dermatology, vol.
This was diagnosed as actinic keratosis
on histological examination.
These include common melanocytic nevi or moles, seborrheic keratosis, lentigines, pigmented actinic keratosis
, pigmented BCC, dermatofibroma etc.
A precancerous skin lesion, actinic keratosis
can be the precursor to squamous cell cancer.
The combination of 5-FU and 0.005% calcipotriene "acts as a potent topical immunotherapeutic agent against actinic keratosis
," he concluded.