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 (ăk-tĭn′ō-mī′sĭn, ăk′tə-nō-)
Any of a class of peptide-containing, often toxic antibiotics that are obtained from soil bacteria.


(Pharmacology) any of several toxic antibiotics obtained from bacteria of the genus Streptomyces, used in treating some cancers; the most commonly used is dactinomycin (actinomycin D)


(ækˌtɪn oʊˈmaɪ sɪn, ˌæk tə noʊ-)

any of a group of related antibiotics derived from streptomyces bacteria, used in the treatment of various cancers.
[1935–1940; actinomyc (es) + -in1]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.actinomycin - any of various red antibiotics isolated from soil bacteria
antibiotic, antibiotic drug - a chemical substance derivable from a mold or bacterium that can kill microorganisms and cure bacterial infections; "when antibiotics were first discovered they were called wonder drugs"
References in periodicals archive ?
3 Twenty patients received the standard protocol of BEP every 21 days; 15 patients received actinomycin-D, high-dose methotrexate, etoposide, and cisplatin (GAMEC) every 14 days; and one patient received cisplatin, vincristine, methotrexate, bleomycin, actinomycin D, cyclophosphamide, etoposide (POMB/ACE) chemotherapy.
Indeed, preparative screening of isolated actinomycetes strains delivered bioactive compounds including actinomycin D and resistomycin from SSA 13 and MKA 17 respectively.
Then the patient was treated with a standard non-gestational choriocarcinoma chemotherapy regimen, in the form of four cycles of EMA/ CO (etoposide, methotrexate, actinomycin D, cyclophosphamide, vincristine).
Chemotherapy (vincristine and actinomycin D) was commenced after histopathological diagnosis.
After four courses of chemotherapy with BEP regimen, for preventing Bleomycin toxicity, two more courses of chemotherapy with VAC regimen (Vincristine, Actinomycin D and Cyclophosphamide) was given.
A PKC inhibitor (GF109203X) and actinomycin D (ActD) were purchased from Wako Pure Chemical Industries, Ltd.
He was treated with right radical orchiectomy and adjuvant chemotherapy (three cycles of bleomycin, actinomycin, cisplatin, and vinblastine).
Vincristine, actinomycin, and cyclophosphamide compared with vincristine, actinomycin, and cyclophosphamide alternating with vincristine, topotecan, and cyclophosphamide for intermediate-risk rhabdomyosarcoma: Children's Oncology Group study D9803.
Thus, the present study aimed to evaluate the MDR-modulatory activity of the quercetin-POM conjugates 2 and 3 on the antitumor activity of the anticancer agents doxorubicin, actinomycin D, vinblastine, and paditaxel against MDR cancer cell lines.
The most commonly used agents are actinomycin D, adriamycin, vincristine, and cyclophosphamide and methotrexate.
It is known that drugs: actinomycin D, doxorubicin, the cis-platin, hydroxyurea and nitrosoureas cause diarrhea [7].
Back in 2003, the team analysed Charlotte's response to the chemotherapy drug Actinomycin D, investigating how the drug was broken down and how long it stayed in her system.