EPZ-5676 is a novel small molecule inhibitor of DOT1L, a histone methyltransferase (HMT) that is critical to the development of a specific type of acute leukemia
defined by rearrangement of the MLL gene (MLL-r leukemia).
for the development, manufacturing and marketing of Leukotuximab, an anti JL-1 antibody for acute leukemia
(AL), including acute myelocytic leukemia (AML) and acute lymphoblastic leukemia (ALL), in the territory of Greater China (including Mainland China, Taiwan, Hong Kong and Macau) and the Middle East (excluding Cyprus, Egypt, Israel and Turkey).
According to the WHO classification of acute leukemia
, diagnosis is based on an arbitrary cut-off point of 20% blasts, as the percentage of bone marrow total or non-erythroid cells, or as the percentage of peripheral blood cells.
With 21 chapters, the book begins by introducing key developments and the latest technologies in acute leukemia
and then prepares the reader with an outline of the edition's contents.
Washington, Apr 14 (AN): A self-feeding "vicious circle" of molecules that keeps acute leukemia
cells alive and growing and that drives the disease forward has been identified by researchers.
An earlier Phase I clinical trial of L-Annamycin in relapsed or refractory acute leukemia
patients, performed by a previous sponsor, suggested potential to treat this disease and was the basis for the initiation by Callisto in December, 2005 of a Phase I clinical trial of L-Annamycin in adult relapsed or refractory ALL patients.
In patients with acute leukemia
who have undergone HLA haplotype-mismatched stem cell transplantation, the administration of granulocyte colony-stimulating factor (G-CSF) to hasten blood cell reconstitution may have more risks than benefits, according to researchers at the University of Perugia in Italy.
13] Histopathologically, this diagnosis is often difficult to make in patients who do not have acute leukemia
In addition, the patient's normal blood cell counts with absence of circulating blasts and partial nodular involvement rather than diffuse replacement of the marrow made the diagnosis of acute leukemia
EPZ-5676, Epizyme's most advanced clinical product candidate, is an inhibitor targeting the DOT1L histone methyltransferase (HMT) for the treatment of mixed lineage leukemia (MLL-r), an aggressive genetically defined subtype of the two most common forms of acute leukemia
, acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
1,2] Based on the results of the first study conducted by the Polycythemia Vera Study Group, Landaw concluded that acute leukemia
is part of the natural history of PV, occurring in 2 of 134 patients treated with phlebotomy alone (1%-2%).
CML is capable of changing to acute leukemia
, which is fast-growing and can spread to any organ in the body.