Additionally, Fodosine(TM) is currently being studied in a Phase I trial with an oral formulation in cutaneous T-cell lymphoma (CTCL), a Phase II trial in chronic lymphocytic leukemia (CLL) and a Phase I/II trial in B-cell acute lymphoblastic leukemia. Fodosine(TM) has been granted Orphan Drug status by the U.S.
"Modern combination chemotherapy and postinduction therapeutic intensification now yield long-term remissions in 75% of children with acute lymphoblastic leukemia, yet 25% ultimately relapse with disease that is resistant.
After interviewing the parents of 83 children with leukemia and 166 control children, the investigators found that 22 mothers of leukemic children and 75 mothers of control children took iron and folate supplements at least once during pregnancy When women who took the supplements were compared with those who didn't, there was a protective association (odds ratio 0.41) between supplementation and risk of acute lymphoblastic leukemia.
Healthcare company Pfizer Inc (NYSE:PFE) reported on Thursday the receipt of approval from the US Food and Drug Administration for Besponsa (inotuzumab ozogamicin) for the treatment of adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (ALL).