L-carnitine is capable of reversing the inhibition of adenine nucleotide
translocase and thus can restore the fatty acid oxidation mechanism which constitutes the main energy source for the myocardium.
The exact causes of fibromyalgia are unknown; however, patients with fibromyalgia have been shown to have an alteration in muscle adenine nucleotide
metabolism, leading to depleted energy reserves (1).
release from isolated perfused guinea pig hearts and extracellular formation of adenosine.
State 3 is especially dependent on the electron transport chain, on the import of substrates into the mitochondrial matrix and on the activities of ATP synthase and adenine nucleotide
translocase (Duan and Karmazym, 1989).
The adenine nucleotide
translocator (ANT) protein is like the nozzle that transports fuel from a gas station pump to a car.
24) Diastolic dysfunction has been identified as a major predictor of CHF risk, and ribose directly maintains adenine nucleotide
pools that are necessary to maintain cardiac diastolic function and increase the energy reserve of the heart.
As part of an ongoing project to identify other proteins which may be affected by TOR or to affect TOR itself, we examined the adenine nucleotide
translocator (ANT), a mitochondrial transporter that moves ADP and ATP across the inner mitochondrial membrane.
synthesis in exercising and endurance-trained skeletal muscle.
Ribose maintains and improves adenine nucleotide
levels in heart and skeletal muscle cells following ischemia or decreased blood flow, or strenuous, high-intensity exercise which reduces oxygen availability to the cell.
Of renewed interest is the inability of the heart to replenish rapidly its adenine nucleotide
pool once it has been diminished during a brief period of regional ischemia [2, 9].
D-ribose has been shown to increase energy production in the heart and skeletal muscle by providing a substrate for the synthesis of adenine nucleotide
, which is, in some circumstances, a rate-limiting factor for the production of ATP.
Platelets of patients with ET are also abnormal in plasma membrane and adenine nucleotide