Significant differences concern only the TSS site which, in case of different species, is different nucleotide-guanine nucleotide in the American mink, cytosine nucleotide in mouse and hamster, adenine nucleotide
in rat (Barta et al.
Results: Mutation analysis revealed a novel homozygous insertion of a single adenine nucleotide
at position 335 in exon 3 of the PAH gene.
A distinctive signature and location, as well as mutations in only the adenine nucleotide
, are hallmarks of this mechanism.
Magnesium Green has been used in non-imaging studies to determine the ATP-ADP exchange rate through the mitochondrial adenine nucleotide
transporter in isolated mitochondria (Chinopoulos et al.
2+] could activate three dehydrogenases of the TCA cycle (pyruvate dehydrogenase, isocitrate dehydrogenase, and oxoglutarate dehydrogenase), the ATP synthase (complex V), and the adenine nucleotide
translocase and then increase the generation of ROS [106-108].
L-carnitine is capable of reversing the inhibition of adenine nucleotide
translocase and thus can restore the fatty acid oxidation mechanism which constitutes the main energy source for the myocardium.
release from isolated perfused guinea pig hearts and extracellular formation of adenosine.
State 3 is especially dependent on the electron transport chain, on the import of substrates into the mitochondrial matrix and on the activities of ATP synthase and adenine nucleotide
translocase (Duan and Karmazym, 1989).
The adenine nucleotide
translocator (ANT) protein is like the nozzle that transports fuel from a gas station pump to a car.
24) Diastolic dysfunction has been identified as a major predictor of CHF risk, and ribose directly maintains adenine nucleotide
pools that are necessary to maintain cardiac diastolic function and increase the energy reserve of the heart.
As part of an ongoing project to identify other proteins which may be affected by TOR or to affect TOR itself, we examined the adenine nucleotide
translocator (ANT), a mitochondrial transporter that moves ADP and ATP across the inner mitochondrial membrane.
Translocator (ANT) mutant sesB showed reduced mitochondrial motility.