(9) Spigelman et al (46) developed a 4-stage classification (0-TV) system for evaluating the severity of duodenal adenomatosis
in individuals with FAP (Table 2), and based on the degree of risk of developing carcinoma, recommendations on the frequency of surveillance and treatment options were issued (Table 3).
The histopathological lesions of epithelial hyperplasia, glandular adenomatosis
, necrosis, haemorrhages and thrombosis of blood vessels and the detection (Figure 3b) of curved intracellular bacteria in epithelial cells (a morphology compatible with Lawsonia intracellularis) by WS silver staining were considered sufficient evidence to establish the diagnosis .
MRI confirmed multiple (10 lesions) fat-containing, slowly enhancing lesions, which were suggestive of liver adenomatosis
. All lesions showed intense [.sup.18]F-FDG uptake (Figure 2).
Renal replacement lipomatosis with coexistent papillary renal cell carcinoma, renal tubulopapillary adenomatosis
and xanthogranulomatous pyelonephritis: an extremely rare association and possible pathogenetic correlation.
Several studies have revealed that primary liver tumors, including benign liver adenomatosis
and HCC, are clustered in HNF1A-DM families [31-33].
Madariaga, "Liver adenomatosis
: clinical, histopathologic, and imaging findings in 15 patients," Radiology, vol.
Focal pancreatic lesions are generally 2-10 mm in size and appear as small regions of islet adenomatosis
(nodular hyperplasia of islet-like cell clusters, including ductuloinsular complexes, Figure 3) (33).
, a premalignant condition, may warrant duodenectomy and pancreatectomy as an attempt to prevent malignant transformation after transplantation .
Pacifici et al., "Diagnosis and treatment of a rare case of adenomatoid odontogenic tumor in a young patient affected by attenuated familial adenomatosis
polyposis (aFAP): case report and 5 years follow-up," European Review for Medical and Pharmacological Sciences, vol.
These phenomena result in gland duct expansion, adenomatosis
, and acinus increase and further cause pathological mammary gland hyperplasia .
Postmortem examination revealed severe, bilateral nephromegaly due to multifocal to coalescing renal tubular adenomas (adenomatosis
), which was complicated with renal gout and soft tissue mineralization.