AMPK is a critical kinase in times of energy depletion when adenosine triphosphate (ATP) levels decline and adenosine monophosphate
(AMP) levels increase.
Role of cyclic adenosine monophosphate
pathway in the mRNA gene expression of IL-6
It is rapidly transported back into cells and degraded into inosine or phosphorylated back to adenosine monophosphate
(AMP) by adenosine deaminase and adenosine kinase, respectively .
Decrease intracellular cyclic adenosine monophosphate
Comparison of the metabolic profiles of human adenomatous polyp (N = 61) and colorectal cancer (CRC) (N = 57) tissue found statistically significant differences (p < 0.05) in their composition of adenosine monophosphate
(AMP), adenine, 5'-methythioadenosine, 3-hydroxybutyric acid, prostaglandin E2, threonine, and glutamine.
It is a vital constituent of bone and cell membranes and of molecules such as adenosine triphosphate (ATP), nicotinamide adenine dinucleotide (NAD), cyclic adenosine monophosphate
(cAMP) and cyclic guanosine monophosphate (cGMP); it is essential for energy storage and metabolism and it is important for cell signalling and enzyme activation.
The possible mechanism by which insulin sensitivity can be improved by exercises is that active muscle contraction causes membrane depolarization that increased cytoplasmic calcium concentration and causes activation of 52--adenosine monophosphate-activated protein kinase that causes translocation of glucose transporter protein-4 (GLUT-4) to the plasma membrane (29) or changing the energy state of the cell as a result of high intracellular ratio of adenosine monophosphate
to adenosine triphosphate (30).
Inhibition of PDE-5 causes increased concentration of cGMP and cyclic adenosine monophosphate
(cAMP) (Bella et al., 2007).
Western-blots were performed to measure the protein expression of the adiponectin-related proteins adiponectin receptor 1 (AdipoR1), peroxisome proliferatoractivated receptor alpha (PPAR[alpha]), adenosine monophosphate
activated protein kinase (AMPK) and phosphorylated adenosine monophosphate
activated protein kinase (P-AMPK), using glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as internal reference.
Experiments with cultured human cells also showed that caffeine competitively bound to adenosine receptors, which disrupted signaling of cyclic adenosine monophosphate
(cAMP), a key part of the circadian clock, the researchers said.
Otezla is an oral small-molecule inhibitor of phosphodiesterase 4 (PDE4) specific for cyclic adenosine monophosphate
Bauer, "Microparticles from pulmonary microvascular endothelial cells contain cyclic adenosine monophosphate