ESSENTIAL DUTIES AND RESPONSIBILITIES: Production of adenoviral
and MVA viral vector seed stocks.
Crystal performed pioneering seminal work on adenoviral
and AAV vectors, which accelerated the translation of gene therapy from the research laboratory to the clinic.
It includes ISO 7 cleanroom suites that will be utilised to manufacture gene therapy vectors, such as adenoviral
vectors, including AdenoVerse vaccines and AdenoVerse cytokine therapies, and cell banks for early stage gene therapy trials.
Yes, we all learned in medical school that it is a cause of epidemic keratoconjunctivitis, but many adenoviral
infections are clinically indistinguishable from infections caused by other viruses.
conjunctivitis can manifest clinically as acute follicular conjunctivitis, pharyngoconjunctival fever, epidemic keratoconjunctivitis (EKC), or chronic conjunctivitis.
By type, the viral vector manufacturing market is segmented into retroviral vectors, adenoviral
vectors, adeno-associated viral vectors, and other viral vectors.
The differentiation of classic Kawasaki disease, atypical Kawasaki disease, and acute adenoviral
infection: use of clinical features and a rapid direct fluorescent antigen test.
The toxicology report was also negative, and a myocardial biopsy revealed adenoviral
genome as the only potential cause of the cardiac arrest.
While most adenoviral
diseases are self-limiting, fatal illness occurs in immunocompromised patients  and, rarely, in healthy children and adults.
The groups were (1) hUCB-MCs transduced with recombinant adenoviruses encoding VEGF and GDNF having therapeutic effect (SCI hUCB-MCs + Ad5-VEGF + Ad5-GDNF, n =12), (2) hUCB-MCs transduced with a recombinant adenoviral
vector encoding EGFP (SCI hUCB-MCs + Ad5-EGFP, n = 10), and (3) without injection (SCI only, n =11).
We have completed a Phase I study that demonstrated the safety of our adenoviral
vectored product and elicited a strong immune response to key antigens in 100% of the dogs treated.