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Stimulation of these receptors on central nervous system neurons causes an intracellular inhibition of adenyl cyclase, closing of influx membrane calcium channels and opening of membrane potassium channels.
Surface binding and sensing by germ tube is an important step for activation of membrane bound adenyl cyclase to form cAMP as external application of cAMP could nullify surface influence as well as temperature influence.
This will lead to the production of prostaglandin which couple with Gi protein and inhibits adenyl cyclase and thus decrease HCl production.
We conclude that decreased vagal modulation of heart rate may occur in hyperthyroidism, which may be restored following adequate treatment by blocking [beta]-receptors and thereby inhibiting the adenyl cyclase-cyclic AMP pathway.
This would then inhibit cAMP generation by adenyl cyclase and block the triggered release of calcium from the sarcoplasmic reticulum even in the presence of normal calcium storage.
Forskolin, one of these diterpenes, directly acts on adenyl cyclase and leads to increased intracellular levels of the second messenger cAMP.
2] muscarinic receptors, via inhibition of adenyl cyclase, cause smooth muscle contraction indirectly by inhibiting sympathetically (beta-adrenoceptor)-mediated relaxation [14].
These metabotropic receptors associated with the G inhibitory protein (Gi/o) reduce cyclic adenosine monophosphate (AMP) through adenyl cyclase inhibition, and induce an increase in potassium (14) by enhanced permeability of inflow and outflow channels, hyperpolarizing the postsynaptic neuron.
2+] channel blockade results in modulation in the adenyl cyclase effectors system activated by [mu],-opioid receptor activation, leading to the suppression of opioid tolerance and restoration of super-sensitivity (Hurle et al.
The pathogenesis of FD involves somatic activating mutation of the gene encoding the alpha subunit of the stimulatory G protein in the bone marrow cells, resulting in locally increased stimulatory activity of adenyl cyclase and cAMP.
Bromocriptine is an ergot alkaloid derivative, structurally related to dopamine (1) Bromocriptine is a dopamine receptor agonist that inhibits prolactin secretion (2, 3, 4, 5) through the inhibition of adenyl cyclase activity (1) and is commonly used in the treatment of hyperprolactinemia, Parkinsonism and acromegaly (6,7).
Clopidogrel may block ADP-induced platelet aggregation via G protein activation and inhibition of adenyl cyclase or it may be totally independent from these factors.
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