adenylate cyclase

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Related to adenylate: adenylate cyclase, adenylic acid

a·den·yl·ate cyclase

(ə-dĕn′əl-ĭt, ăd′n-ĭl′ĭt) also a·den·yl cyclase (ə-dĕn′əl, ăd′n-ĭl)
n.
An enzyme that catalyzes the formation of cyclic AMP from ATP and plays a key role in signal transduction.

References in periodicals archive ?
ALD1910 to enter clinical development in 2019: Alder continues to advance its preclinical candidate, ALD1910, a monoclonal antibody targeting PACAP (pituitary adenylate cyclase-activating peptide) for migraine prevention.
Of which, Gas can activate adenylate cyclase to catalyze the production of cAMP, and activate the cAMP-PKA signaling pathway (Takemori and Okamoto, 2008; Ciccone et al., 2010; Thompson et al., 2013).
The agreement is related to an investigational compound targeting the pituitary adenylate cyclase receptor 1 (PAC1) in non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and various other gastrointestinal and liver diseases.
Deficient adenylate cyclase regulatory protein in renal membranes from a patient with pseudohypoparathyroidism.
G-protein coupled receptor mutation analysis was completed on native liver tissue obtained at transplant which identified one of the typical pathogenic variants (c.602G>A.p.R201H) in exon 8 of the GNAS1 (adenylate cyclase stimulatory G protein) gene that has been associated with the MAS phenotype (1, 2, 3).
On the other hand muscarinic [M.sub.2] and [M.sub.4] receptors preferentially couple to G[alpha]i/o subunit that inhibits adenylate cyclase and reduce the production of second messenger cyclic adenosine monophosphate (cAMP).
The [MT.sub.1] receptor activation causes [G.sub.1] adenylate cyclase inhibition via proteins.
The adenylate energy charge decreases rapidly to ~ 0.4-0.5 during the initial hours and remains above 0.8 after 2 h compared to the normal value in the brain of ~ 0.93.
What's the probability that the nucleotide you pick, is an adenylate (A)?