adenylate cyclase

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Related to adenylate cyclase: cyclic AMP, Phospholipase C, Protein kinase A

a·den·yl·ate cyclase

(ə-dĕn′əl-ĭt, ăd′n-ĭl′ĭt) also a·den·yl cyclase (ə-dĕn′əl, ăd′n-ĭl)
An enzyme that catalyzes the formation of cyclic AMP from ATP and plays a key role in signal transduction.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
On the other hand, [M.sub.2] receptor activation by pilocarpine inhibits adenylate cyclase. This causes a reduction in the acetylcholine release and the excitability of the brain (27).
Vasopressin and isoproterenol activate adenylate cyclase in the guinea pig inner ear.
However, in thyroid carcinomas with a poor response to TSH and high basal adenylate cyclase activity, mutations in TSHR and Gs were reported in 12% of FTC and in 13% of PTC (16).
Furthermore, PEMFs did not change the adenylate cyclase activity in the absence or in the presence of forskolin, a direct activator of this enzyme, and in cAMP production.
Adenylate cyclase activators such as IBMX and forskolin strongly potentiated glucose-induced insulin secretion by several folds from perifused EndoC-[beta]H1 pseudoislets, which is due to a stimulation of cAMP generation [6, 18].
In the presence of SQ 22536 (inhibitors of cyclic adenylate cyclase), no modification of the pharmacological response was observed in SHR and WKY animals (Fig.
VIP inhibits HC proliferation by eliciting signal transduction through one of its G protein-coupled receptors (GPCR), designated vasoactive pituitary adenylate cyclase activating peptide receptor 1 (VPAC1).
During acquisition, 50 [micro]M Forskolin (adenylate cyclase activator) is added at 5 minutes of time and 10 [micro]M Rolipram+ 500 [micro]M IBMX (phosphodiesterase inhibitors) were added at time point of 15 minutes.
It can grow after having been in contact with diseased animals and animal products.1 The anthrax bacillus takes effect in the tissue with two significant enzymes: The lethal factor (endopeptidase) causing cell damage and adenylate cyclase responsible for oedema.23 There are 3 forms of anthrax identified as cutaneous gastro-intestinal and inhalation.