Among the first to explore NK adoptive immunotherapy
were the groups at Frankfurt University and Basel University Hospital, focusing on pediatric and young adult patients.
using CARs T-cells is emerging as a novel approach to pancreatic cancer immunotherapy.
Schuessler et al., "Pre-emptive and therapeutic adoptive immunotherapy
for nasopharyngeal carcinoma: Phenotype and effector function of T cells impact on clinical response," OncoImmunology, vol.
Novick et al., "T-cell adoptive immunotherapy
of metastatic renal cell carcinoma," Urology, vol.
Mirza et al., "A phase II study of adoptive immunotherapy
using dendritic cells pulsed with tumor lysate in patients with hepatocellular carcinoma," Hepatology, vol.
Earlier studies on adoptive immunotherapy
have been summarised in recent reviews [47, 55-58].
Genetic engineering of T cells for adoptive immunotherapy
. Immunol Res, 2008, 42, 166-181.
The principle behind the company's business is based on the emerging field of adoptive immunotherapy
, or biological therapy, which has been successfully used around the world to treat a wide variety of cancers and chronic viral infections.
It is the first time that adoptive immunotherapy
with engineered human T cells has demonstrated in vivo efficacy in mice.
"We view T-cell adoptive immunotherapy
as particularly appealing for patients whose tumor burdens might be too large or too aggressive to warrant administration with cancer vaccines."
A major difficulty in adoptive immunotherapy
has been identifying those lymphocytes among all those present in the body that are most active against a tumor.
Rosenberg calls his treatment with the special lymphocytes "adoptive immunotherapy
." This therapy has produced some remarkable effects including the complete disappearance of cancer in patients who are near death.