Further continued usage of topical steroids could eventually lead to severe systemic side effects: damage of the hypothalamic-pituitary-adrenal (HPA) axis and adrenal cortex
Approximately 80 to 90 percent of the adrenal cortex
must be damaged before clinical diagnosis is accurate, which means by the time you realize your dog is sick, he is in trouble.
The adrenal cortex
produces a variety of steroidal hormones, including mineralocorticoids (which help maintain electrolyte balance and blood pressure) and glucocorticoids (including Cortisol, which helps regulate body metabolism).
The zona fasciculata accounts for 80% of the size of the adrenal cortex
. The inner medulla consists of chromaffin cells that produce adrenaline (epinephrine) and noradrenaline (norepinephrine) that regulate the "flight or fight" response to stress.
X-linked adrenoleukodystophy (ALD) is a peroxisomal disorder that affects both central nervous system and adrenal cortex
and shows a wide range of clinical spectrum.
The exterior part, called the adrenal cortex
is responsible for releasing corticosteroid hormone, Glucocorticoids, such as Cortisol and cortisone, are corticosteroids that break down amino acids in order to generate glucose for use during physical activity.
Cosyntropin depot is an alcohol-free formulation of a synthetic ACTH analogue, a hormone secreted from the pituitary gland that is responsible for the stimulation of the adrenal cortex
. Cosyntropin depot is composed of the first 24 of 39 amino acids found in ACTH, which retains the full steroidogenic activity of the natural hormone.
This disease is mainly caused by damage to the adrenal cortex
that may be due to autoimmune disorders including chronic thyroiditis, Graves' disease, myasthenia gravis and pernicious anemia; infectious diseases such as tuberculosis, HIV and fungal infections; tumor and hemorrhage into the adrenal gland.
These are benign tumors derived from the adrenal cortex
. The vast majority of adenomas are non-hyperfunctioning.
An aldosterone producing tumor of the adrenal cortex
is the main cause of primary hyperaldosteronism and should always be excluded when in the presence of severe hypertension, since the standard treatment is surgical and leads to a stabilization of the tension pattern after a few months.
The adrenal cortex
is red to light brown in colour and is composed of three zones.