The release of CRH triggers pituitary production of adrenocorticotropic hormone (ACTH), which then triggers the adrenal cortex
to produce DHEA and the glucocorticoid cortisol and the adrenal medulla to release epinephrine and norepinephrine, typically called "fight or flight" hormones.
The adrenal cortex
which includes the zona fasciculata and the zona reticularis, is involved in the production of essential hormones such as glucocorticoids and androgens respectively.
Hyperplasia of different zona of adrenal cortex
was found in different types of hormonally active adrenal myelolipoma, with mature adipose tissue and hematopoietic elements in the adrenal tissues.
Primary adrenal carcinoma (ACC) is a rare, aggressive malignancy arising from the adrenal cortex
These receptors are activated by hormones released in response to stress by the adrenal cortex
Further, with our full-section staining we confirmed reactivity within admixed normal adrenal cortex
Under normal conditions, the HPA axis has a complex negative feedback between hypothalamus, pituitary, and adrenal cortex
ACTH travels via the systemic circulation to reach the adrenal cortex
, wherein glucocorticoids are synthesized and released (see Herman et al.
Addison's disease, or primary adrenal insufficiency, is a chronic disorder of the adrenal cortex
resulting in inadequate production of glucocorticoids and mineralocorticoids.
The other stress hormone is cortisol, a steroid hormone secreted in the adrenal cortex
The pituitary, in turn, secretes adrenocorticotropic hormone (ACTH), which regulates the adrenal cortex
, and modulates production by the ovaries, of the key sex hormones estrogen and progesterone.
Congenital adrenal hyperplasia (CAH)  (OMIM 201910) due to 21-hydroxylase deficiency(21-OHD) is an autosomal recessive disorder of the adrenal cortex
characterized by impairment of cortisol biosynthesis, with or without impairment of aldosterone biosynthesis (1).