It originates from the sympathetic nervous system, most frequently from the adrenal medulla
. The heterogeneous clinical behavior of neuroblastoma is dependent on numerous clinical as well as biological features (1).
The parenchyma of the adrenal medulla
is specialised for neurohormonal release, itself being a modified sympathetic ganglion.
tumorlerine ait serilerin incelenmesinde bildirilen degisik oranda kompozit doku varligi bilgisi ile birlikte sayica az rastlanan KAMT'lerin daha sistemik degerlendirilmesi, feokromositoma olarak rapor edilen adrenal tumorlerin daha ayrintili histopatolojik incelenmesi gerekliligini ortaya koymaktadir.
PCCs are uncommon neuroendocrine tumors that arise from chromaffin cells of the adrenal medulla
and produce excessive amounts of catecholamines, which are responsible for hypertensive surges, palpitations, headache, and diaphoresis (5).
They formed cellular columns directed towards the adrenal medulla
, separated from each other by sinusoids (Fig.
Pheochromocytoma is a rare neoplasm arising from chromaffin cells in the adrenal medulla
and is characterized by increased catecholamine synthesis and release.
Normally, norepinephrine is mainly secreted by sympathetic nerve terminals and the brain, and epinephrine is mainly secreted by the adrenal medulla
. When healthy volunteers were upright, normal blood pressure was maintained by norepinephrine.
Pheochromocytoma and paraganglioma (P-PGL) are catecholamine-secreting tumors, which respectively arise from chromaffin cells of the adrenal medulla
and the sympathetic ganglia.
The cellular compartment of the adrenal medulla
is necrotic with intermingled fibrin exudation (star) (haematoxylin and eosin, original magnification 4x insert, original magnification 20x).
Signs and symptoms such as headache, palpitations, and hypertension resembling a pheochromocytoma may also be seen as a result of compression of adrenal medulla
by cysts that grow into the adrenal gland .
Vitamin C is an important cofactor for both adrenal cortex and adrenal medulla
. Endocr Res.
The clinical picture of abnormal electrolytes results and hyperpigmentation of the skin and mucosa elicited investigation into Addison's disease due to bilateral adrenal hemorrhage, which was then confirmed by the detection of low plasma cortisol levels (3.8-11.0 [micro]g/L) and high adrenocorticotropin levels (524-888 pg/ml), leaving the function of adrenal reticular zone and adrenal medulla