Development of what Zomedica believes is the first-ever point-of-care assay for canine endogenous adrenocorticotropic hormone
(eACTH) and an assay for feline thyroid stimulating hormone (feline TSH) demonstrates the potential of TRUFORMA.
The company believes that each may become the first-ever point-of-care assay for canine endogenous adrenocorticotropic hormone
(eACTH) and for feline thyroid stimulating hormone (feline TSH).
A standard dose adrenocorticotropic hormone
(ACTH) test (30 [micro]g/kg/dose) revealed an inadequate stimulated cortisol and high 17OHP levels, suggesting simple virilising congenital adrenal hyperplasia (CAH) likely due to 21-hydroxylase deficiency (Table 1).
The adrenal glands are guided by a hormone produced by the pituitary gland called ACTH or adrenocorticotropic hormone
. They produce two important types of hormones, glucocorticoids and mineralocorticoids.
Methods used to evaluate adrenal fatigue included salivary cortisol rhythm, direct awakening cortisol, cortisol awakening response, morning serum cortisol, night salivary cortisol, area under curve measurement, dexamethasone suppression test, dehydroepiandosterone sulfate or DHEA-S, adrenocorticotropic hormone
or ACTH, mental stress test, 24-hour urinary free cortisol, cosyntrophin stimulation test, morning area under curve, corticotrophin releasing hormone, total urinary cortisol metabolites and oral glucose tolerance test.
The results from this ongoing Phase II open-label study demonstrated a reduction of at least 50% from baseline in 17-hydroxyprogesterone, or 17-OHP, and adrenocorticotropic hormone
, or ACTH, levels in more than 50% of CAH patients treated with NBI-74788 for 14 days.
Hormonal work-up confirmed elevated follicle-stimulating hormone, normal thyroid-stimulating hormone, normal prolactin, and normal basal and adrenocorticotropic hormone
(ACTH) stimulated cortisol levels.
The acute hormonal effects of OP are deficiencies in the thyroid-stimulating hormone (TSH), adrenocorticotropic hormone
(ACTH), and insulin-like growth factor 1 (IGF-1) hormone correlated with the levels of cholinesterase.
His endocrinological data revealed unelevated adrenocorticotropic hormone
(ACTH), serum aldosterone low-normal while plasma renin was very high.
After this, the hypothalamus signals the pituitary gland to secrete adrenocorticotropic hormone
(ACTH), which is responsible for activating the adrenal cortex, which then releases the hormones Cortisol, cortisone, and aldosterone.
The pituitary gland (located near the brain) acts to stimulate production of Cortisol by secreting adrenocorticotropic hormone