2) Are ruminants able to cleave plant specific metabolites like glycosides to the respective aglycon
? These questions are commonly investigated by performing additional in vivo studies in ruminants according to OECD 503 (OECD, 2007a), which are treated with radiolabeled test item, housed in metabolic cages for at least 5 days, and sacrificed at the end of the study.
Two rhamnose units are attached to its aglycon
portion, naringenin, at the 7-carbon position.
Three main phenolic groups could be clearly distinguished: phenolic alcohols (hydroxytyrosol, tyrosol, and tyrosol glucoside), flavonoids (luteolin rutinoside, 2 isomers of luteolin glucoside, 2 isomers of diosmin, apigenin rutinoside, apigenin glucoside, chryseriol glucoside, luteolin, apigenin, rutin, quercetin, gallocatechin, taxifolin, and diosmetin), and various secoiridoids (particularly, oleuropein with 3 isomers, methoxyoleuropein, ligstroside, oleuropein aglycon
derivative and related compounds such as elenolic acid glucoside isomers, and secologanoside).
The main components of these compounds are glycosides that consist of a glycon part and an aglycon
part connected through a glycosidic bond that can be created by a glycosylation reaction.
Among secondary metabolites, diterpene glycosides of Stevia rebaudiana Bertoni plants with steviol (13-hydroxy-ent-kaur-16-en-19-oic acid) as aglycon
is of particular interest .
Several oligosaccharides have been isolated from plants which contain L-rhamnose with aglycon
moiety at C-4 position  e.g.
The comparison of thioglucosides 2a-2i allows a preliminary elucidation of the effect of aglycon
upon their inhibitory activity.
In the present study, the effect of neomycin on the anaerobic microflora which hydrolyses the vicine to its aglycon
divicine and consequently the toxic and lethal effect was established.
A team at Yale, led by chemist Seth Herzon, managed to create the chemical called lomaiviticin aglycon
, opening up new avenues of exploration into novel chemotherapies that could target cancer stem cells, thought to be the precursors to tumors in a number of different cancers including ovarian, brain, lung, prostate and leukemia.
Ltd 8C34 Aconitum UAB 8NE12 Acyfabrik SA 8B62 Adelphi Healthcare Packaging 8C71 Aeropump, GmbH 8F84 Agenda 1 Analytical Services Limited 8NE11 Agenolab GMBH & Co KG 8D27 Aglycon
8E84 Alfa Wassermann 8B49 Algorithme Pharma Inc.
Quercetin itself is an aglycon
or aglucone that does not possess a carbohydrate moiety in its structure.
The same curves were used for the quantitation of piceid (resveratrol glucoside), rhapontigenin (aglycon
of rhapontin), and deoxyrhapontigenin (aglycon
of deocyrhapontin), respectively, taking into account the ratios of molecular weights and molar absorptivities.