agonist


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Related to agonist: Agonist muscle, Dopamine agonist

ag·o·nist

 (ăg′ə-nĭst)
n.
1. Physiology A contracting muscle that is resisted or counteracted by another muscle, the antagonist.
2. A substance that can combine with a receptor on a cell to initiate signal transduction.
3. One involved in a struggle or competition.

[Late Latin agōnista, contender, from Greek agōnistēs, from agōn, contest; see agony.]

agonist

(ˈæɡənɪst)
n
1. (Physiology) any muscle that is opposed in action by another muscle. Compare antagonist2
2. a competitor, as in an agon
[C17: from Greek agōn agon]

ag•o•nist

(ˈæg ə nɪst)

n.
1. a person engaged in a contest, conflict, struggle, etc., esp. the protagonist in a literary work.
2. a person who is torn by inner conflict.
3. a contracting muscle whose action is opposed by another muscle. Compare antagonist (def. 3).
4. a chemical substance capable of activating a receptor to induce a full or partial pharmacological response. Compare antagonist (def. 5).
[1620–30; < Late Latin agōnista < Greek agōnistḗs contestant =agṓn agon + -istēs -ist]

ag·o·nist

(ăg′ə-nĭst)
A muscle that actively contracts to produce a desired movement. Compare antagonist.

agonist

one who contends for a prize in public games. — agonistic, agonistical, adj.
See also: Athletics
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.agonist - the principal character in a work of fictionagonist - the principal character in a work of fiction
antihero - a protagonist who lacks the characteristics that would make him a hero (or her a heroine)
2.agonist - someone involved in a contest or battle (as in an agon)agonist - someone involved in a contest or battle (as in an agon)
contestant - a person who participates in competitions
adversary, antagonist, opposer, resister, opponent - someone who offers opposition
3.agonist - a muscle that contracts while another relaxesagonist - a muscle that contracts while another relaxes; "when bending the elbow the biceps are the agonist"
antagonistic muscle - (physiology) a muscle that opposes the action of another; "the biceps and triceps are antagonistic muscles"
4.agonist - (biochemistry) a drug that can combine with a receptor on a cell to produce a physiological reaction
drug - a substance that is used as a medicine or narcotic
biochemistry - the organic chemistry of compounds and processes occurring in organisms; the effort to understand biology within the context of chemistry
Translations
agonista
agonista
References in periodicals archive ?
a privately held biopharmaceutical company developing breakthrough immune modulatory medicines, announced today that research findings from the Company's RORgamma agonist program will be presented at this week's annual meeting of the Society for Immunotherapy of Cancer, taking place in National Harbor, MD, November 4-8, 2015.
The study among 552 young-adult injecting-drug users, who were followed for 680 person-years, documented 171 cases of HCV infection, but found the rate of infection was significantly lower among those on opioid agonist maintenance therapy, compared with those on non-opioid agonist treatment or opioid agonist detoxification therapy.
The study among 552 young-adult injecting drug users, who were followed for 680 person-years, documented 171 cases of HCV infection, but found the rate of infection was significantly lower among those on opioid agonist maintenance therapy, compared with those on non--opioid agonist treatment or opioid agonist detoxification therapy
The authors from Heptares describe for the first time how StaR technology enables the study of isolated GPCRs locked in conformations that correspond to agonist or antagonist pharmacology, and the elucidation of their respective 3D structures.
The flare-up regimens involve early follicular phase beginning of the GnRH agonist, with minimal delay before the onset of gonadotrophin administration (1, 2).
We calculated compound reproducibility for all NR assays in both agonist and antagonist mode using the ratio readout.
This study focused on generating agonist ligand data for the alpha-2 AR which mediates the antiepileptic effects of the neurotransmitter norepinephrine in the hippocampus (2).
On the basis of preclinical evaluation in animal models of human conditions, one might expect a Delta agonist to show effect in inflammatory pain, among other pain conditions.
Under the terms of the agreement, Merck will receive worldwide exclusive rights to a number of Idera's agonist compounds targeting TLR 7, 8 and 9 for use in combination with Merck's therapeutic and prophylactic vaccines under development for oncology, infectious diseases and Alzheimer's disease.
Chochinov and colleagues at Sunnybrook and Women's College Health Sciences Centre, Toronto, culled the medical literature for studies published between 1966 and 2001 that compared ephedrine with an [alpha]-1 agonist for the treatment or prevention of hypotension due to neuraxial blockade during elective C-sections among women carrying full-term pregnancies.
The agonist "significantly attenuated all [physical] withdrawal symptoms measured," the investigators assert.
To obtain a copy of the Academy's position statement on the beta-2 agonist, or for more information on asthma, interested persons may call 1-800-822-ASMA (2762).