A study of the incidence of agranulocytosis
and aplastic anemia associated with the oral use of metamizole sodium in Poland.
One Baczol formulation also contained metamizole (or dipyrone), a nonsteroidal antiinflammatory drug formerly widely prescribed outside the United States (under trade names including Analgin, Dipirona, Novalgin, and Optalgin) as an analgesic and antipyretic, and banned by the FDA in 1977 because of its association with agranulocytosis
In 1975, clozapine entered Finland and following reports about clozapine-induced agranulocytosis
and related mortality and morbidity in Finland and other countries, it was collected from the market .
Leukopenia, Neutropenia, and Agranulocytosis
: Leukopenia/ neutropenia has been reported during treatment with antipsychotic agents.
They commonly addressed care of patients with medical conditions, such as agranulocytosis
, pyelitis and acute nephritis, or patients receiving new treatments such as sulphathiazole for staphylococcal septicaemia.
Optimal therapy is now perhaps dictated by the appearance of toxicity or adverse effects such as agranulocytosis
, liver or renal dysfunction.
Less apparent is any type of inflammatory infiltrate in this pattern that usually occurs in a patient with severe bone marrow suppression or agranulocytosis
A major hematological side effect of mirtazapine is agranulocytosis
. Herein we report a patient with depression that developed severe neutropenia-associated thrombocytopenia during treatment with mirtazapine; the patient was safely treated by switching to another drug.
Clozapine was first developed and marketed in the 1960s, but was withdrawn from use in 1975 because of an associated high risk of agranulocytosis
. However the drug returned to use in 1989, following trial results that demonstrated its unique effectiveness in treatment-resistant schizophrenia.
(10) Case reports have also associated pSS and agranulocytosis
. (11) This could be from either reduced bone marrow neutrophil production, or increased peripheral destruction.
During this period the patient was admitted in hospital with diarrhoea and febrile agranulocytosis
. Neutropenic colitis was diagnosed and confirmed by CT scan, the patient being treated with broad spectrum antibiotics leading to a good recovery.
In controlled hypothyroidism patients, the dentist Hypothyorid patient on propylthiouracil treatment must be monitored for possible agranulocytosis
, hypo- proteinemia or bleeding, and a complete blood count lest including prothrombin time be performed before doing any invasive procedure.