agrin


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agrin

(əˈɡrɪn)
adv
in a grinning manner

agrin

(əˈɡrɪn)
n
biology a proteoglycan particularly known for its role in the development of the neuromuscular junction, when it is secreted by motor neuron axons
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in classic literature ?
Another minute brought them up with the rear-guard, where every man marched with his beard on his shoulder and a face which was agrin with merriment.
MG would seem to be due to a reduced number of acetylcholine receptors (AChR) at the postsynaptic muscle membrane due to circulating anti-AChR antibodies, or may be due to antibodies to muscle-specific tyrosine kinase (anti-MuSK), LRP4, and agrin. (20,21) The incidence of MG ranges from 0.3 to 2.8 cases per 100,000 and is estimated to affect more than 700,000 people worldwide.
Muscle-derived agrin in cultured myotubes: expression in the basal lamina and at induced acetylcholine receptor clusters.
Other ECM components found in vertebrates such as agrin, thrombospondin, and secreted protein acidic and rich in cysteine (SPARC)/osteonectin are also conserved in sponges [11].
(a) A B C D E 1 POS1 POS1 POS1 NEG Activin A 2 POS1 POS1 POS1 NEG Activin A 3 Fas Ligand Fractalkine GM-CSF ICAM-1 IFN-[gamma] 4 Fas Ligand Fractalkine GM-CSF ICAM-1 IFN-[gamma] 5 IL-13 Leptin LIX L-Selectin MCP-1 6 IL-13 Leptin LIX L-Selectin MCP-1 7 TNF-[alpha] VEGF NEG NEG NEG 8 TNF-[alpha] VEGF NEG NEG NEG F G H I 1 Agrin CD86 [beta]-NGF CINC-1 2 Agrin CD86 [beta]-NGF CINC-1 3 IL-1[alpha] IL-1[beta] IL-1 R6 IL-2 4 IL-1[alpha] IL-1[beta] IL-1 R6 IL-2 5 MIP-3[alpha] MMP-8 PDGF-AA Prolactin R 6 MIP-3[alpha] MMP-8 PDGF-AA Prolactin R 7 NEG NEG NEG NEG 8 NEG NEG NEG NEG J K L 1 CINC-2[alpha] CINC-3 CNTF 2 CINC-2[alpha] CINC-3 CNTF 3 IL-4 IL-6 IL-10 4 IL-4 IL-6 IL-10 5 RAGE Thymus Chemokine-1 TIMP-1 6 RAGE Thymus Chemokine-1 TIMP-1 7 NEG NEG POS1 8 NEG NEG POS1
Then new strategy was presented by using linker proteins (agrin, laminin-[alpha]1, and nidogen-1) that can be incorporated into adeno-associated virus (AAV) vectors.
When targeted by autoantibodies, Lrp4 cannot bind its ligand agrin, which results in faulty neuromuscular junction development that leads to a serious disease called myasthenia gravis [67].
ECM proteins such as the heparan sulfate proteoglycan (HSPG) agrin have been associated with senile plaques (SPs) and neurofibrillary tangles (NFTs) [86, 87].
The Cross Keys (the-crosskeys.com) gastro-pub on Water Lane, offers an impressive list, which ranges from the in-house Transmission at PS5.30, Magic Rock's gluten-free Fantasma at PS7.40 and the exotic Pina Agrin Sour Ale with Pineapple from Colorado at PS18.50.
The Cross Keys (the-crosskeys.com) gastro-pub on Water Lane, part of Leeds' North Bar group, offers an impressive list, which ranges from the in-house Transmission at PS5.30, Magic Rock's gluten-free Fantasma at PS7.40 and the exotic Pina Agrin Sour Ale with Pineapple from Colorado at PS18.50.