Hu, "Nanoparticle based on poly(ionic liquid) as an efficient solid immobilization catalyst for aldol reaction
and multicomponent reaction in water," ACS Applied Materials & Interfaces, vol.
The organocatalytic aldol reaction
 is one of the most powerful methods for forming C-C bonds in a highly stereocontrolled manner.
reported the application of the chiral ionic liquid 1 and its derivatives as an organocatalyst for aldol reaction
; however, the aldol products were obtained in moderate yields and selectivities (up to 80% ee) .
Extending the coverage of its predecessor, Modern Aldo Reactions, this reference focuses on the latest developments and offers new tools for use of the aldol reaction
in the development of natural products and pharmaceuticals.
Moreover, PEG is inexpensive, easy to handle, thermally stable, non-toxic, and recyclable in various organic transformations , such as for example, Heck reaction , catalytic hydrogenations , asymmetric dihydroxylation reaction , Baylis-Hillman reaction , Biginelli reaction , Suzuki-Miyaura reaction, Stille cross-coupling reaction , Wacker reaction  and asymmetric aldol reaction
Key steps included a diisopinocampheylchloroborane (DPC)-catalysed aldol reaction
that was shown to be highly sensitive to traces of moisture.
A recent communication from the Journal of Organic Chemistry describing an asymmetric, biologically-catalyzed aldol reaction
was used as the basis for this study.
Triacetone alcohol and semiphorone undergo retrograde aldol reaction
catalyzed by carbonaceous residues adhering to the surface of the injector port of the gas chromatograph during GC-MS analysis.
Some examples have been reported on the use of organocatalysts in water which is an important approach to the principles of green chemistry .The aldol reaction
is one of the mostimportant carbon-carbon bond forming reactions in modern organic synthesis as a key step in natural product synthesis and for the rapid access to polyoxygenated compounds.
The thermoresponsive polymer in water aggregate to form a rather hydrophobic reaction field and the substrates are probably concentrated and promoted the aldol reaction
in the resulting hydrophobic field.