aldose


Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.
Related to aldose: Aldose reductase

al·dose

 (ăl′dōs′, -dōz′)
n.
Any of a class of monosaccharide sugars containing an aldehyde group.

aldose

(ˈældəʊs; -dəʊz)
n
(Elements & Compounds) a sugar that contains the aldehyde group or is a hemiacetal
[C20: from ald(ehyde) + -ose2]

al•dose

(ˈæl doʊs)

n.
a sugar containing the aldehyde group or its equivalent.
[1890–95; ald (ehyde) + -ose2]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.aldose - a monosaccharide sugar that contains the aldehyde group or is hemiacetal
aldohexose - a monosaccharide sugar having six carbon atoms and an aldehyde group
monosaccharide, monosaccharose, simple sugar - a sugar (like sucrose or fructose) that does not hydrolyse to give other sugars; the simplest group of carbohydrates
Translations
References in periodicals archive ?
Applied Therapeutics announced the initiation of a Phase 3 registrational trial for AT-001, a novel, potent and selective aldose reductase inhibitor, in Diabetic Cardiomyopathy.
In tissues where glucose intake is independent of insulin, excess glucose is typically metabolized to sorbitol through the polyol pathway and this reaction is catalyzed by the aldose reductase enzyme.
The study, referred to as ACTION-Galactosemia, was initiated in June 2019and is designed to investigate the safety and pharmacokinetics (PK) of AT-007, a central nervous system (CNS) penetrant Aldose Reductase (AR) inhibitor in healthy volunteers, and biomarker effects in adult subjects with Galactosemia.
The enzyme aldose reductase (AR) catalyses the reduction of glucose to sorbitol, but sorbitol is produced faster than it is converted to fructose meaning that it accumulates, creating a hyperosmotic effect that results in an infusion of fluid to counteract the osmotic gradient; this leads to the collapse and eventual liquefaction of lens fibres, which results in the lens becoming opaque.
Newer drugs called "aldose reductase inhibitors" have been shown in a laboratory to delay or prevent cataract formation in diabetic dogs.
The aldose reductase inhibitory capacity of Sorbus domestica fruit extracts depends on their phenolic content and may be useful for the control of diabetic complications.
It has been hypothesized that swelling develops in the fluid content of peripheral nerves due to an increase in the levels of aldose reductase enzyme, which converts glucose to sorbitol in patients with diabetes (3).
In addition, ranirestat, an inhibitor of the enzyme aldose reductase, which has an early role in the development of DR [36], exerts neuroprotective effects by reducing GFAP accumulation and preventing hyperglycemia-associated structural damage of the retina [31].
Dasatinib is a dual Src/Abl [1] and pan-Src [2] kinase inhibitor, zopolrestat [3] and lidorestat [4] are aldose reductase inhibitors used for the treatment of diabetic complications, and raloxifene is the first clinically available selective estrogen receptor modulator (SERM) used to prevent both osteoporosis and breast cancer [5-8].
Secondly, glucose may induce myoIns depletion by activation of the glucose-sorbitol pathway, in which glucose is first converted to sorbitol by aldose reductase and then to fructose by sorbitol dehydrogenase, as observed in diabetic patients [47].