alkylating agent


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alkylating agent

(ˈælkɪˌleɪtɪŋ)
n
(Pharmacology) any cytotoxic drug containing alkyl groups, such as chlorambucil, that acts by damaging DNA; widely used in chemotherapy
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.alkylating agent - an antineoplastic drug used to treat some forms of cancer
antineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function
chlorambucil, Leukeran - an alkalating agent (trade name Leukeran) used to treat some kinds of cancer
References in periodicals archive ?
MMS, an alkylating agent, is known for its ability to interact with DNA in vitro and in vivo producing genotoxic damage.
The disease must be refractory to both rituximab and an alkylating agent.
Summary: Pyrroloimidazoles have been synthesized by diastereoselective of 1,3-dipolar cycloaddition by using 4, 5-dihydroimidazolium ylides with an alkylating agent and base.
Cumulative alkylating agent exposure and semen parameters in adult survivors of childhood cancer: A report from the St.
1) Patients with therapy-related acute leukemias from alkylating agents generally show a latency of 3-7 years from exposure to the alkylating agent and often have an insidious course, with the development of MDS prior.
Each wafer contains the nitrosourea alkylating agent carmustine distributed in a biodegradable polymer matrix.
Premature menopause and secondary malignancies--two LEs associated with the alkylating agent cyclophosphamide--were identified by only 71% and 62% of oncologists, respectively, along with 15% and 17%, respectively, of PCPs.
Their topics include human biotransformation, analytical tools and approaches for metabolic identification in drug metabolism, the unanticipated loss of N2 from novel DNA alkylating agent laromustine by collision-induced dissociation, and strategies for detecting reactive intermediates in drug discovery and development.
6) Dosages and regimens of chemotherapeutic agents have been published with different results and are usually derived from current small animal or human protocols, although most are based on an alkylating agent paired with prednisone.
Currently, the drug is approved to treat the disease in patients that have been treated with an alkylating agent and have failed fludarabine therapy.
MB is a noncorrosive alkylating agent and does not damage food, furnishings, documents, or even sensitive electronic equipment.
TEMODAL (temozolomide) Capsule is an oral, cytotoxic alkylating agent indicated for treating glioblastoma multiforme (GBM).