alleles


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Related to alleles: genotype, Multiple alleles

alleles

Two or more genes which control the same characteristic.
References in periodicals archive ?
Preclinical data from HD patient-derived fibroblasts and neurons demonstrated that a single administration of ZFP-TFs resulted in the selective repression of over 99% of HD-causing HTT disease alleles over a wide dose range, while preserving the expression of at least 86% of healthy wild-type HTT alleles.
Table 2: Frequency of alleles and genotypes of the FOXO3 SNP rs2802288 and Minor Allele Frequency (MAF).
Peak height of SNP alleles in the sequencing map and allele frequencies which are estimated by MWsnap are shown in Table II.
Of the 33 different combinations, the highest combinations observed in SHWs were 'null, 6+8, 2.1+10.5' followed by 'null, 6+8, 1.5+10' and '2*, 6+8, 2+12', while, the Pakistani cultivars and land races harbored 'null, 20, 12+2' and '1, 7+8, 2+12' alleles.
Progression to AIDS has been strongly associated with the human leukocyte antigen B (HLA-B) alleles, particularly HLA-B*57 and HLA-B*27 allele groups (protection), and HLA-B*35 (susceptibility), due to the restricted recognition of HIV epitopes by cytotoxic immune system cells [4].
HLA-B alleles were analyzed by the polymerase chain reaction-sequence-specific oligonucleotide probe (PCR-SSOP) assay and Luminex[TM] Multiplex Technology with well-established protocols [22].
The present data explains prevalence of alleles and genotypes frequency of CAT-21A/T (rs7943316) gene polymorphism in healthy individuals.
HLA-DRB1 alleles and genotypes in patients with relapsing-remitting multiple sclerosis from western Mexico: a pilot study
The protective FOXO3 allele (G allele) is associated with longevity with one G allele (GT genotype) doubling the odds to live to 100 and two G alleles (GG genotype) tripling the odds to live to 100.
The chi-square test ([chi square]) was applied to analyze the accordance with Hardy-Weinberg equilibrium and the differences in the distribution of alleles and genotypes.
The OR values of the two-allele polymorphism were calculated from the following two models, respectively: (1) allele model (mutant alleles versus wild-type alleles); (2) dominant model (heterozygous + homozygous mutant versus homozygous wild-type).
Given the need for routine HLA genotyping for histocompatibility testing, the Immunogenetics community has characterized over 14000 named HLA alleles using a variety of techniques including traditional serological approaches and more recent DNA-based methodologies including restriction fragment length polymorphism (RFLP) analysis, PCR-sequence specific oligonucleotide probes (PCR-SSOP), sequence specific primer PCR (SSP-PCR), Sanger sequence based typing (SBT) and most recently next generation sequencing (NGS) (8-19).